Target cell-specific involvement of presynaptic mitochondria in post-tetanic potentiation at hippocampal mossy fiber synapses.

Target cell-specific involvement of presynaptic mitochondria in post-tetanic potentiation at hippocampal mossy fiber synapses. Research Abstract Details 

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Target cell-specific involvement of presynaptic mitochondria in post-tetanic potentiation at hippocampal mossy fiber synapses. Abstract Text:

Doyun Lee,Kyu-Hee Lee,Won-Kyung Ho,Suk-Ho Lee,Doyun Lee,Kyu-Hee Lee,Won-Kyung Ho,Suk-Ho Lee,Doyun Lee,Kyu-Hee Lee,Won-Kyung Ho,Suk-Ho Lee,

Previous studies indicate that boutons from the same axon exhibit distinct Ca(2+) dynamics depending on the postsynaptic targets. Mossy fibers of hippocampal granule cells innervate synaptic targets via morphologically distinct boutons. We investigated mitochondrial involvement in the generation of post-tetanic residual Ca(2+) (Ca(res)) at large and small en passant mossy fiber boutons (MFBs). Mitochondria limited the [Ca(2+)](i) build-up during high-frequency stimulation (HFS) at large MFBs, but not at small MFBs. The amount of Ca(res), quantified as a time integral of residual [Ca(2+)](i), was significantly larger at large MFBs than at small MFBs, and that at large MFBs was substantially attenuated by inhibitors of mitochondrial Ca(2+) uniporter and mitochondrial Na(+)/Ca(2+) exchanger (mitoNCX). In contrast, blockers of mitoNCX had no effect on the Ca(res) at small MFBs. Post-tetanic Ca(res) has been proposed as a mechanism for post-tetanic potentiation (PTP). We examined mitochondrial involvement in PTP at mossy fiber synapses on hilar mossy cells (MF-->MC synapse) and on hilar interneurons (MF-->HI synapse), which are presumably innervated via large and small MFBs, respectively. Consistent with the differential contribution of mitochondria to Ca(res) at large and small MFBs, mitoNCX blockers significantly reduced the PTP at the MF-->MC synapse, but not at the MF-->HI synapse. In contrast, protein kinase C (PKC) inhibitors significantly reduced the PTP at MF-->HI synapse, but not at the MF-->MC synapse. These results indicate that mitochondria- and PKC-dependent PTP are expressed at distinct hilar mossy fiber synapses depending on postsynaptic targets.

Target cell-specific involvement of presynaptic mitochondria in post-tetanic potentiation at hippocampal mossy fiber synapses. Publishing Authors By Initials

D Lee,KH Lee,WK Ho,SH Lee,D Lee,KH Lee,WK Ho,SH Lee,D Lee,KH Lee,WK Ho,SH Lee,

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Target cell-specific involvement of presynaptic mitochondria in post-tetanic potentiation at hippocampal mossy fiber synapses. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of neuroscience : the official journal

VOLUME: 27

Page Numbers: 13603-13

Journal Abbreviation: J. Neurosci.

ISSN: 1529-2401

DAY: 12

MONTH: Dec

YEAR: 2007

Target cell-specific involvement of presynaptic mitochondria in post-tetanic potentiation at hippocampal mossy fiber synapses. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Target cell-specific involvement of presynaptic mitochondria in post-tetanic potentiation at hippocampal mossy fiber synapses.

AFFILIATION: National Research Laboratory for Cell Physiology, Department of Physiology, Seoul National University College of Medicine and Neuroscience Research Institute, Seoul National University Medical Research Center, Seoul 110-799, Korea.

Country: United States

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MEDLINETA: J Neurosci

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