Tanshinone congeners improve memory impairments induced by scopolamine on passive avoidance tasks in mice.

Tanshinone congeners improve memory impairments induced by scopolamine on passive avoidance tasks in mice. Research Abstract Details 

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Tanshinone congeners improve memory impairments induced by scopolamine on passive avoidance tasks in mice. Abstract Text:

Dong Hyun Kim,Su Jin Jeon,Ji Wook Jung,Seungjoo Lee,Byung Hoon Yoon,Bum Young Shin,Kun Ho Son,Jae Hoon Cheong,Yeong Shik Kim,Sam Sik Kang,Kwang Ho Ko,Jong Hoon Ryu,Dong Hyun Kim,Su Jin Jeon,Ji Wook Jung,Seungjoo Lee,Byung Hoon Yoon,Bum Young Shin,Kun Ho Son,Jae Hoon Cheong,Yeong Shik Kim,Sam Sik Kang,Kwang Ho Ko,Jong Hoon Ryu,

Tanshinones are a group of diterpenoids found in the roots of Salvia miltiorrhiza Bunge which has been used to treat cardiac disease. In the present study, we investigated the effect of the tanshinone congeners, tanshinone I, tanshinone IIA, cryptotanshinone, and 15, 16-dihydrotanshinone I, on learning and memory impairments induced by scopolamine (1 mg/kg, i.p.), a muscarinic antagonist, using passive avoidance tasks in mice. Tacrine was used as a positive control. Tanshinone I (2 or 4 mg/kg, p.o.), tanshinone IIA (10 or 20 mg/kg, p.o.), cryptotanshinone (10 mg/kg, p.o.), and 15, 16-dihydrotanshinone I (2 or 4 mg/kg, p.o.) significantly reversed scopolamine-induced cognitive impairments (P<0.05). Tanshinone I (2 mg/kg, p.o.) and tanshinone IIA (10 or 20 mg/kg, p.o.) were also reversed diazepam-induced cognitive dysfunctions (P<0.05). In addition, cryptotanshinone and 15, 16-dihydrotanshinone I were found to have an inhibitory effect on acetylcholinesterase in vitro with IC(50) values 82 and 25 microM, respectively. Furthermore, cryptotanshinone inhibited acetylcholinesterase activity for 3 h and 15, 16-dihydrotanshinone I for 6 h in an ex-vivo study. These results suggest that tanshinone congeners may be useful for the treatment of cognitive impairment and that their beneficial effects are mediated, in part, by cholinergic signaling enhancement.

Tanshinone congeners improve memory impairments induced by scopolamine on passive avoidance tasks in mice. Publishing Authors By Initials

DH Kim,SJ Jeon,JW Jung,S Lee,BH Yoon,BY Shin,KH Son,JH Cheong,YS Kim,SS Kang,KH Ko,JH Ryu,DH Kim,SJ Jeon,JW Jung,S Lee,BH Yoon,BY Shin,KH Son,JH Cheong,YS Kim,SS Kang,KH Ko,JH Ryu,

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Tanshinone congeners improve memory impairments induced by scopolamine on passive avoidance tasks in mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European journal of pharmacology

VOLUME: 574

Page Numbers: 140-7

Journal Abbreviation: Eur. J. Pharmacol.

ISSN: 0014-2999

DAY: 31

MONTH: 07

YEAR: 2007

Tanshinone congeners improve memory impairments induced by scopolamine on passive avoidance tasks in mice. Information

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LANGUAGE: eng

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AFFILIATION: Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Hoeki-dong, Dongdaemoon-Ku, Seoul 130-701, South Korea.

Country: Netherlands

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MEDLINETA: Eur J Pharmacol

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