Tambouranolide, a new cytotoxic hydroxybutanolide from a Tambourissa sp. (Monimiaceae).

Tambouranolide, a new cytotoxic hydroxybutanolide from a Tambourissa sp. (Monimiaceae). Research Abstract Details 

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Tambouranolide, a new cytotoxic hydroxybutanolide from a Tambourissa sp. (Monimiaceae). Abstract Text:

Brent J Yoder,Shugeng Cao,Andrew Norris,James S Miller,Fidisoa Ratovoson,Rabodo Andriantsiferana,Vincent E Rasamison,David G I Kingston,

A new cytotoxic hydroxybutanolide, tambouranolide, has been isolated by solid phase extraction from an ethanol extract of the dried roots of a species of Tambourissa (Monimiaceae) from the Madagascar rainforest. The structure was elucidated through the interpretation of spectral data and its comparison to data reported in the literature for related molecules. The compound showed moderate in vitro cytotoxicity with an IC50 of 8 micro g mL(-1) in the A2780 human ovarian cancer cell line assay.

Tambouranolide, a new cytotoxic hydroxybutanolide from a Tambourissa sp. (Monimiaceae). Publishing Authors By Initials

BJ Yoder,S Cao,A Norris,JS Miller,F Ratovoson,R Andriantsiferana,VE Rasamison,DG Kingston,

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Tambouranolide, a new cytotoxic hydroxybutanolide from a Tambourissa sp. (Monimiaceae). Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Natural product research

VOLUME: 21

Page Numbers: 37-41

Journal Abbreviation: Nat. Prod. Res.

ISSN: 1478-6419

DAY: 3

MONTH: Jan

YEAR: 2007

Tambouranolide, a new cytotoxic hydroxybutanolide from a Tambourissa sp. (Monimiaceae). Information

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LANGUAGE: eng

NlmUniqueID: 101167924

Tambouranolide, a new cytotoxic hydroxybutanolide from a Tambourissa sp. (Monimiaceae). Keywords Mesh Terms:

KEYWORDS: Spectrometry, Mass, Fast Atom Bombardmen

MESH TERMS: chemistry

Chemical & Substance for Abstract: Tambouranolide, a new cytotoxic hydroxybutanolide from a Tambourissa sp. (Monimiaceae). Information

Substance Name: Furans

Registry Number: 0

Grant and Affiliation Information for Tambouranolide, a new cytotoxic hydroxybutanolide from a Tambourissa sp. (Monimiaceae).

AFFILIATION: Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

Country: England

AGENCY: United States FIC

GRANT: U01 TW000313

ACRONYM: TW

MEDLINETA: Nat Prod Res

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