Tales from the crypts: regulatory peptides and cytokines in gastrointestinal homeostasis and disease.

Tales from the crypts: regulatory peptides and cytokines in gastrointestinal homeostasis and disease. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Tales from the crypts: regulatory peptides and cytokines in gastrointestinal homeostasis and disease. Abstract Text:

Juanita L Merchant,

The gastrointestinal (GI) tract is composed of a diverse set of organs that together receive extracorporeal nutrition and convert it to energy substrates and cellular building blocks. In the process, it must sort through all that we ingest and discriminate what is useable from what is not, and having done that, it discards what is "junk." To accomplish these many and varied tasks, the GI tract relies on endogenous enteric hormones produced by enteroendocrine cells and the enteric nervous system. In many instances, the mediators of these tasks are small peptides that home to the CNS and accessory gut organs to coordinate oral intake with digestive secretions. As the contents of ingested material can contain harmful agents, the gut is armed with an extensive immune system. A breach of the epithelial barrier of the GI tract can result in local and eventually systemic disease if the gut does not mount an aggressive immune response.

Tales from the crypts: regulatory peptides and cytokines in gastrointestinal homeostasis and disease. Publishing Authors By Initials

JL Merchant,

For similar peptides research abstracts see: peptides research

PUBMED ID PMID:

MEDLINE DATE:

Tales from the crypts: regulatory peptides and cytokines in gastrointestinal homeostasis and disease. Journal Published:

PUBLICATION TYPE: Review

Journal: The Journal of clinical investigation

VOLUME: 117

Page Numbers: 6-12

Journal Abbreviation: J. Clin. Invest.

ISSN: 0021-9738

DAY: 3

MONTH: Jan

YEAR: 2007

Tales from the crypts: regulatory peptides and cytokines in gastrointestinal homeostasis and disease. Information

Number of References: 80

LANGUAGE: eng

NlmUniqueID: 7802877

Tales from the crypts: regulatory peptides and cytokines in gastrointestinal homeostasis and disease. Keywords Mesh Terms:

KEYWORDS: Peptides

MESH TERMS: physiology

Chemical & Substance for Abstract: Tales from the crypts: regulatory peptides and cytokines in gastrointestinal homeostasis and disease. Information

Substance Name: Peptides

Registry Number: 0

Grant and Affiliation Information for Tales from the crypts: regulatory peptides and cytokines in gastrointestinal homeostasis and disease.

AFFILIATION: Division of Gastroenterology, Department of Internal, University of Michigan, Ann Arbor, Michigan, USA. merchanj@umich.edu

Country: United States

AGENCY: United States NIDDK

GRANT: R01 DK061410

ACRONYM: DK

MEDLINETA: J Clin Invest

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Tales from the crypts: regulatory peptides and cytokines in gastrointestinal homeostasis and disease Related Publications

• A role for CITED2, a CBP/p300 interacting protein, in colon cancer cell invasion.
• Changes in attentional performance of children and young adults with localized primary brain tumors after conformal radiation therapy.
• Clinical evaluation and MR imaging features of popliteal artery entrapment and cystic adventitial disease.
• Comparison of the vastus-splitting and median parapatellar approaches for primary total knee arthroplasty: a prospective, randomized study. Surgical technique.
• DENTAL EDUCATION IN RETROSPECT. II. POST-GRADUATE EDUCATION.
• Dental colleges and the staff.
• Diet patterns related to caries in low-income adults.
• Does parental physical violence reduce children's standardized test score performance?
• Economic development and health status among the poor in squatter settlements of Karachi.
• Endoscopic ultrasound and computed tomography predictors of pancreatic cancer resectability.
• FEA1, FEA2, and FRE1, encoding two homologous secreted proteins and a candidate ferrireductase, are expressed coordinately with FOX1 and FTR1 in iron-deficient Chlamydomonas reinhardtii.
• Health effects of airborne exposures from concentrated animal feeding operations.
• Helicobacter pylori-induced atrophic gastritis progressing to gastric cancer exhibits sonic hedgehog loss and aberrant CDX2 expression.
• Intestinal overexpression of ZNF148 suppresses ApcMin/+ neoplasia.
• Investigation of the mechanics of Type III stapes columella tympanoplasty using laser-Doppler vibrometry.
• MRI of hypertrophic cardiomyopathy: part 2, Differential diagnosis, risk stratification, and posttreatment MRI appearances.
• MRI of hypertrophic cardiomyopathy: part I, MRI appearances.
• Manganese deficiency in Chlamydomonas results in loss of photosystem II and MnSOD function, sensitivity to peroxides, and secondary phosphorus and iron deficiency.
• Measurements of human middle- and inner-ear mechanics with dehiscence of the superior semicircular canal.
• Multiloculated cystadenoma of the liver.
• Paget disease of the temporal bone.
• Polycystic ovary syndrome in the Indian Subcontinent.
• Predicting pediatric distress during radiation therapy procedures: the role of medical, psychosocial, and demographic factors.
• Proteomic methods for biomarker discovery in urine.
• Re-expression of sonic hedgehog and reduction of CDX2 after Helicobacter pylori eradication prior to incomplete intestinal metaplasia.
• Reduced pepsin a processing of sonic hedgehog in parietal cells precedes gastric atrophy and transformation.
• Sonographic appearance of primary testicular lymphoma.
• Tales from the crypts: regulatory peptides and cytokines in gastrointestinal homeostasis and disease.
• Three-dimensional virtual model of the human temporal bone: a stand-alone, downloadable teaching tool.
• Urine PGE-M: A metabolite of prostaglandin E2 as a potential biomarker of advanced colorectal neoplasia.