Taking the tension out of the portal system. An approach to the management of portal hypertension in the 1990s.

Taking the tension out of the portal system. An approach to the management of portal hypertension in the 1990s. Research Abstract Details 

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Taking the tension out of the portal system. An approach to the management of portal hypertension in the 1990s. Abstract Text:

P Mac Mathuna,D Westaby,R Williams,

The past decade saw the emergence of sclerotherapy and vasoactive pharmacologic agents as alternatives to surgery in the prevention and treatment of variceal haemorrhage. Despite encouraging results from clinical trials with regard to the prevention of rebleeding, these modalities of therapy have made no major impact on survival. This failure to alter radically the clinical outcome results from the fact that in many patients with cirrhosis death is primarily related to the degree of hepatic decompensation rather than the prevention or control of variceal bleeding. Advances in our knowledge of vasoactive mediators, receptor function, and altered vascular reactivity have provided increased insight into the circulatory disturbances that characterise cirrhosis and portal hypertension. Earlier and more aggressive pharmacologic intervention with single or combination drug therapy may inhibit fibrogenesis, reduce portal vascular resistance, and improve liver function and therefore provide effective prophylaxis against variceal haemorrhage. The emergence of reliable prognostic indices for variceal bleeding should help identify patients at risk who would benefit from prophylaxis with either drugs or sclerotherapy. Transplantation will be increasingly considered in the patient at high risk of recurrent bleeding before the stage of severe hepatic decompensation (the risks of the transplant then become very much greater), as the definitive means for reducing mortality in cirrhosis and portal hypertension.

Taking the tension out of the portal system. An approach to the management of portal hypertension in the 1990s. Publishing Authors By Initials

P Mac Mathuna,D Westaby,R Williams,

For similar therapeutics: drug therapy: sclerotherapy research abstracts see: therapeutics: drug therapy: sclerotherapy research

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Taking the tension out of the portal system. An approach to the management of portal hypertension in the 1990s. Journal Published:

PUBLICATION TYPE: Review

Journal: Scandinavian journal of gastroenterology. Suppleme

VOLUME: 175

Page Numbers: 131-45

Journal Abbreviation: Scand. J. Gastroenterol. Suppl

ISSN: 0085-5928

DAY: 13

MONTH: 02

YEAR: 1990

Taking the tension out of the portal system. An approach to the management of portal hypertension in the 1990s. Information

Number of References: 126

LANGUAGE: eng

NlmUniqueID: 437034

Taking the tension out of the portal system. An approach to the management of portal hypertension in the 1990s. Keywords Mesh Terms:

KEYWORDS: Sclerotherapy

MESH TERMS: physiology

Chemical & Substance for Abstract: Taking the tension out of the portal system. An approach to the management of portal hypertension in the 1990s. Information

Substance Name: Adrenergic beta-Antagonists

Registry Number: 0

Grant and Affiliation Information for Taking the tension out of the portal system. An approach to the management of portal hypertension in the 1990s.

AFFILIATION: Liver Unit, King's College School of Medicine and Dentistry, London, U.K.

Country: NORWAY

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MEDLINETA: Scand J Gastroenterol Suppl

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