T regulatory cell levels decrease in people infected with Schistosoma mansoni on effective treatment.

T regulatory cell levels decrease in people infected with Schistosoma mansoni on effective treatment. Research Abstract Details 

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T regulatory cell levels decrease in people infected with Schistosoma mansoni on effective treatment. Abstract Text:

Kanji Watanabe,Pauline N M Mwinzi,Carla L Black,Erick M O Muok,Diana M S Karanja,W Evan Secor,Daniel G Colley,Kanji Watanabe,Pauline N M Mwinzi,Carla L Black,Erick M O Muok,Diana M S Karanja,W Evan Secor,Daniel G Colley,

Schistosomiasis mansoni is usually a chronic infection that leads to long-term, systemic exposure to schistosome antigens. Experimental Schistosoma mansoni infection is associated with immunoregulatory mechanisms, including T regulatory cells (Treg) that may help control morbidity and dampen resistance to re-infection. We now show that some schistosomiasis mansoni patients have high proportions of CD3(+)/CD4(+)/CD25(high) Treg. On effective treatment with praziquantel, these high Treg percentages decrease, and fewer of the remaining Treg express CD45RO. The proportion of Treg in S. mansoni-infected patients is inversely related to their percentage of activated, putative effector T cells (CD3(+)/CD4(+)/CD25(medium)/HLA-DR(+) cells). We conclude some, but not all, schistosomiasis mansoni patients develop high percentages of circulating Treg, and effective treatment both decreases the levels of these cells and changes their phenotypes, possibly because of the removal of constant exposure to antigens from intravascular, egg-producing adult worms.

T regulatory cell levels decrease in people infected with Schistosoma mansoni on effective treatment. Publishing Authors By Initials

K Watanabe,PN Mwinzi,CL Black,EM Muok,DM Karanja,WE Secor,DG Colley,K Watanabe,PN Mwinzi,CL Black,EM Muok,DM Karanja,WE Secor,DG Colley,

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T regulatory cell levels decrease in people infected with Schistosoma mansoni on effective treatment. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The American journal of tropical medicine and hygi

VOLUME: 77

Page Numbers: 676-82

Journal Abbreviation: Am. J. Trop. Med. Hyg.

ISSN: 0002-9637

DAY: 5

MONTH: Oct

YEAR: 2007

T regulatory cell levels decrease in people infected with Schistosoma mansoni on effective treatment. Information

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LANGUAGE: eng

NlmUniqueID: 370507

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Grant and Affiliation Information for T regulatory cell levels decrease in people infected with Schistosoma mansoni on effective treatment.

AFFILIATION: Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia 30602-3799, USA.

Country: United States

AGENCY: United States NIAID

GRANT: T32 AI 060546

ACRONYM: AI

MEDLINETA: Am J Trop Med Hyg

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