T-cell subsets and expression of integrins in peripheral blood of patients with migraine.

T-cell subsets and expression of integrins in peripheral blood of patients with migraine. Research Abstract Details 

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T-cell subsets and expression of integrins in peripheral blood of patients with migraine. Abstract Text:

P Martelletti,S Morrone,

Neurogenic inflammation is considered as an animal model of human migraine attacks. Using flow cytometry, we examined T-cell subsets and their integrin expression in the peripheral blood of 32 migraine patients in order to evaluate a possible inflammatory process in humans, as postulated in the migraine animal model. Our results show that migraine patients have a significant increased proportion of T-helper (47.4 +/- 6.3% vs 43.2 +/- 5.8%; p < 0.01) and T-helper memory cells (23.6 +/- 5.9 vs 20.3 +/- 6.5%; p < 0.01). Moreover, the 22 migraine patients without aura also exhibited an increase of LFA-1 expression of T-helper cells (34.7 +/- 11.5%) compared to the 35 controls (27.5 +/- 12.0%; p < 0.01). These preliminary results support the hypothesis that immunological mechanisms (such as an enhanced lymphocyte endothelium interaction) could be part of the migraine pathophysiology in humans.

T-cell subsets and expression of integrins in peripheral blood of patients with migraine. Publishing Authors By Initials

P Martelletti,S Morrone,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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T-cell subsets and expression of integrins in peripheral blood of patients with migraine. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cephalalgia : an international journal of headache

VOLUME: 19

Page Numbers: 713-7; discussion 697

Journal Abbreviation: Cephalalgia

ISSN: 0333-1024

DAY: 11

MONTH: Oct

YEAR: 1999

T-cell subsets and expression of integrins in peripheral blood of patients with migraine. Information

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LANGUAGE: eng

NlmUniqueID: 8200710

T-cell subsets and expression of integrins in peripheral blood of patients with migraine. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: blood

Chemical & Substance for Abstract: T-cell subsets and expression of integrins in peripheral blood of patients with migraine. Information

Substance Name: Integrins

Registry Number: 0

Grant and Affiliation Information for T-cell subsets and expression of integrins in peripheral blood of patients with migraine.

AFFILIATION: Department of Neurology, University of Munich, Germany. moem@brain.nefo.med.uni-muenchen.de

Country: NORWAY

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MEDLINETA: Cephalalgia

REFSOURCE: Cephalalgia. 2000 Mar;20(2):136

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