T cell populations propagating in the peripheral blood of patients with drug eruptions.

T cell populations propagating in the peripheral blood of patients with drug eruptions. Research Abstract Details 

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T cell populations propagating in the peripheral blood of patients with drug eruptions. Abstract Text:

Daisuke Nishio,Kunio Izu,Kenji Kabashima,Yoshiki Tokura,Daisuke Nishio,Kunio Izu,Kenji Kabashima,Yoshiki Tokura,

BACKGROUND: In the non-immediate type of drug eruptions, the populations of circulating T cells may be altered as a consequence of T cell responses to a culprit drug. OBJECTIVE: The aim of this study was to investigate differences among the types of drug eruptions in propagating T cell populations of the patients' peripheral blood. METHODS: The type of eruptions were divided into three categories: (1) generalized maculopapular eruption (MPE), (2) erythema multiforme (EM)/Stevens-Johnson syndrome (SJS), and (3) drug-induced hypersensitivity syndrome (DIHS) or drug rash with eosinophilia and systemic symptoms (DRESS). T cell populations were phenotypically analyzed by flow cytometry in the percentage of T helper (Th) 1 (CXCR3+CD4+), Th2 (CCR4+CD4+), Tc1 (CXCR3+CD8+), and Tc2 (CCR4+CD8+) subsets and their activation states as assessed by CD69, CD25 or HLA-DR positivity. RESULTS: Upon occurrence of both MPE and EM/SJS, Th2 cells outnumbered Th1 cells, whereas Tc1 and Tc2 cells differentially predominated in EM/SJS and MPE, respectively. An increase of HLA-DR+CD8+ cells in EM/SJS type provided another supportive evidence for Tc1 stimulation. In DIHS, during the development of the second wave of eruption and/or liver dysfunction associated with anti-HHV6 antibody elevation, CD4+ cells were gradually decreased, but CD8+ cells were inversely increased. Tc1 cells were increased as well as Th1 cells. Finally, in all the three groups, there existed a considerable number of CD25+CTLA-4-CD4+ T cells. CONCLUSION: Our study suggests that Th2/Tc2 and Th2/Tc1 cells mediate MPE and EM/SJS, respectively, and Tc1 cells are involved in the pathogenesis of DIHS at the late stage.

T cell populations propagating in the peripheral blood of patients with drug eruptions. Publishing Authors By Initials

D Nishio,K Izu,K Kabashima,Y Tokura,D Nishio,K Izu,K Kabashima,Y Tokura,

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T cell populations propagating in the peripheral blood of patients with drug eruptions. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of dermatological science

VOLUME: 48

Page Numbers: 25-33

Journal Abbreviation: J. Dermatol. Sci.

ISSN: 0923-1811

DAY: 29

MONTH: 06

YEAR: 2007

T cell populations propagating in the peripheral blood of patients with drug eruptions. Information

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LANGUAGE: eng

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Grant and Affiliation Information for T cell populations propagating in the peripheral blood of patients with drug eruptions.

AFFILIATION: Department of Dermatology, University of Occupational and Environmental Health, 1-1 Iseigaoka, Kitakyushu 807-8555, Japan.

Country: Netherlands

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MEDLINETA: J Dermatol Sci

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