T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20.

T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20. Research Abstract Details 

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T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20. Abstract Text:

Beatrice Coornaert,Mathijs Baens,Karen Heyninck,Tine Bekaert,Mira Haegman,Jens Staal,Lijun Sun,Zhijian J Chen,Peter Marynen,Rudi Beyaert,

The paracaspase MALT1 mediates T cell antigen receptor-induced signaling to the transcription factor NF-kappaB and is indispensable for T cell activation and proliferation. Enhanced expression of MALT1 or aberrant expression of a fusion protein of the apoptosis inhibitor API2 and MALT1 has been linked to mucosa-associated lymphoid tissue lymphoma. Despite the presence of a caspase-like domain, MALT1 proteolytic activity has not yet been demonstrated. Here we show that T cell antigen receptor stimulation induced recruitment of the NF-kappaB inhibitor A20 into a complex of MALT1 and the adaptor protein Bcl-10, leading to MALT1-mediated processing of A20. API2-MALT1 expression likewise resulted in cleavage of A20. MALT1 cleaved human A20 after arginine 439 and impaired its NF-kappaB-inhibitory function. Our studies identify A20 as a substrate of MALT1 and emphasize the importance of MALT1 proteolytic activity in the 'fine tuning' of T cell antigen receptor signaling.

T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20. Publishing Authors By Initials

B Coornaert,M Baens,K Heyninck,T Bekaert,M Haegman,J Staal,L Sun,ZJ Chen,P Marynen,R Beyaert,

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T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nature immunology

VOLUME: 9

Page Numbers: 263-71

Journal Abbreviation: Nat. Immunol.

ISSN: 1529-2916

DAY: 27

MONTH: 01

YEAR: 2008

T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20. Information

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LANGUAGE: eng

NlmUniqueID: 100941354

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Grant and Affiliation Information for T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20.

AFFILIATION: Department of Molecular Biology, Ghent University, B-9052 Ghent, Belgium.

Country: United States

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MEDLINETA: Nat Immunol

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