Systemic RNAi in Caenorhabditis elegans.

Systemic RNAi in Caenorhabditis elegans. Research Abstract Details 

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Systemic RNAi in Caenorhabditis elegans. Abstract Text:

C P Hunter,W M Winston,C Molodowitch,E H Feinberg,J Shih,M Sutherlin,A J Wright,M C Fitzgerald,

RNA interference (RNAi) in Caenorhabditis elegans induced by ingestion or injection of double-stranded RNA (dsRNA) spreads throughout the organism and is even transmitted to the progeny. We have identified two proteins required for spreading of RNAi, SID-1 and SID-2, whose structure, subcellular localization, and expression pattern have been informative for how dsRNA can be transported into and between cells. SID-1 is a transmembrane protein that functions as a pore or channel that transports dsRNA into and out of cells. Proteins homologous to SID-1 are present in a wide range of invertebrate and vertebrate animals but are absent from plants. SID-2 is a small transmembrane protein that is expressed in the gut and localizes strongly to the luminal membrane where it appears to act as a receptor for uptake of dsRNA from the environment. Characterization of SID-2 activity in a variety of Caenorhabditis nematodes indicates that C. elegans SID-2 may have a novel activity.

Systemic RNAi in Caenorhabditis elegans. Publishing Authors By Initials

CP Hunter,WM Winston,C Molodowitch,EH Feinberg,J Shih,M Sutherlin,AJ Wright,MC Fitzgerald,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: sequence homology: sequence homology, amino acid research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: sequence homology: sequence homology, amino acid research

PUBMED ID PMID:

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Systemic RNAi in Caenorhabditis elegans. Journal Published:

PUBLICATION TYPE: Review

Journal: Cold Spring Harbor symposia on quantitative biolog

VOLUME: 71

Page Numbers: 95-100

Journal Abbreviation: Cold Spring Harb. Symp. Quant.

ISSN: 0091-7451

DAY: 3

MONTH: 12

YEAR: 2006

Systemic RNAi in Caenorhabditis elegans. Information

Number of References: 24

LANGUAGE: eng

NlmUniqueID: 1256107

Systemic RNAi in Caenorhabditis elegans. Keywords Mesh Terms:

KEYWORDS: Sequence Homology, Amino Acid

MESH TERMS: metabolism

Chemical & Substance for Abstract: Systemic RNAi in Caenorhabditis elegans. Information

Substance Name: SID-1 protein, C elegans

Registry Number: 0

Grant and Affiliation Information for Systemic RNAi in Caenorhabditis elegans.

AFFILIATION: Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM06989

ACRONYM: GM

MEDLINETA: Cold Spring Harb Symp Quant Bi

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