Systemic autoimmune disorders in celiac disease.

Systemic autoimmune disorders in celiac disease. Research Abstract Details 

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Systemic autoimmune disorders in celiac disease. Abstract Text:

Alessio Fasano,

PURPOSE OF REVIEW: Celiac disease is an immune-mediated disorder clinically characterized by a multitude of symptoms and complications. The comorbidity between celiac disease and other autoimmune disorders has been clearly established. RECENT FINDINGS: Two main theories have been postulated to explain this comorbidity: (1) linkage disequilibrium between the genes responsible for celiac disease and those responsible for the coexpressed autoimmune diseases or (2) untreated celiac disease leading to the onset of other autoimmune diseases. This article reviews the current literature supporting either theory and places the current knowledge in the field within the context of the most recent data on the pathogenesis of celiac disease. SUMMARY: The current literature did not clearly establish which of the two theories explain the comorbidity between celiac disease and other autoimmune disorders. There is, however, growing evidence that the loss of the intestinal barrier function typical of celiac disease could be responsible of the onset of other autoimmune disease. This concept implies that the autoimmune response can be theoretically stopped and perhaps reversed if the interplay between autoimmune predisposing genes and trigger(s) is prevented or eliminated by a prompt diagnosis and treatment.

Systemic autoimmune disorders in celiac disease. Publishing Authors By Initials

A Fasano,

For similar biological phenomena, cell phenomena, and immunity: immunity: immunity, natural research abstracts see: biological phenomena, cell phenomena, and immunity: immunity: immunity, natural research

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Systemic autoimmune disorders in celiac disease. Journal Published:

PUBLICATION TYPE: Review

Journal: Current opinion in gastroenterology

VOLUME: 22

Page Numbers: 674-9

Journal Abbreviation: Curr. Opin. Gastroenterol.

ISSN: 0267-1379

DAY: 3

MONTH: Nov

YEAR: 2006

Systemic autoimmune disorders in celiac disease. Information

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LANGUAGE: eng

NlmUniqueID: 8506887

Systemic autoimmune disorders in celiac disease. Keywords Mesh Terms:

KEYWORDS: Immunity, Natural

MESH TERMS: immunology

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Grant and Affiliation Information for Systemic autoimmune disorders in celiac disease.

AFFILIATION: Center for Celiac Research and Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. afasano@mbrc.umaryland.edu

Country: United States

AGENCY: United States NIDDK

GRANT: DK-48373

ACRONYM: DK

MEDLINETA: Curr Opin Gastroenterol

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