Systemic and acquired immune responses in Alzheimer's disease.

Systemic and acquired immune responses in Alzheimer's disease. Research Abstract Details 

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Systemic and acquired immune responses in Alzheimer's disease. Abstract Text:

Markus Britschgi,Tony Wyss-Coray,

Alzheimer's disease (AD) is a neurodegenerative disorder characterized clinically by a progressive cognitive decline and dementia. AD brains are marked by amyloid plaques and neurofibrillary tangles, neuronal cell loss, and a prominent activation of glial cells, and innate immune responses. A growing number of studies in AD have also reported alterations in systemic immune responses including changes in lymphocyte and macrophage distribution and activation, the presence of autoantibodies, or abnormal cytokine production. Studies in animal models for AD support the notion that immune cells infiltrate the brain and may modulate the disease. Here we will review evidence for systemic alterations in immune responses and a role for acquired immunity in AD and discuss their potential contribution to the disease.

Systemic and acquired immune responses in Alzheimer's disease. Publishing Authors By Initials

M Britschgi,T Wyss-Coray,

For similar proteins: nerve tissue proteins research abstracts see: proteins: nerve tissue proteins research

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Systemic and acquired immune responses in Alzheimer's disease. Journal Published:

PUBLICATION TYPE: Review

Journal: International review of neurobiology

VOLUME: 82

Page Numbers: 205-33

Journal Abbreviation: Int. Rev. Neurobiol.

ISSN: 0074-7742

DAY: 3

MONTH: 12

YEAR: 2007

Systemic and acquired immune responses in Alzheimer's disease. Information

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LANGUAGE: eng

NlmUniqueID: 374740

Systemic and acquired immune responses in Alzheimer's disease. Keywords Mesh Terms:

KEYWORDS: Nerve Tissue Proteins

MESH TERMS: biosynthesis

Chemical & Substance for Abstract: Systemic and acquired immune responses in Alzheimer's disease. Information

Substance Name: Nerve Tissue Proteins

Registry Number: 0

Grant and Affiliation Information for Systemic and acquired immune responses in Alzheimer's disease.

AFFILIATION: Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA.

Country: United States

AGENCY: United States NIA

GRANT: AG20603

ACRONYM: AG

MEDLINETA: Int Rev Neurobiol

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