Synthetic strategies to alpha-trifluoromethyl and alpha-difluoromethyl substituted alpha-amino acids.

Synthetic strategies to alpha-trifluoromethyl and alpha-difluoromethyl substituted alpha-amino acids. Research Abstract Details 

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Synthetic strategies to alpha-trifluoromethyl and alpha-difluoromethyl substituted alpha-amino acids. Abstract Text:

The combination of the unique physical and chemical properties of fluorine with proteinogenic amino acids represents a new approach to the design of biologically active compounds including peptides with improved pharmacological parameters. Therefore, the development of routine synthetic methods which enable the effective and selective introduction of fluorine into the desired amino acids from readily available starting materials is of significant synthetic importance. The scope of this critical review is to summarize the most frequently employed strategies for the synthesis of alpha-difluoromethyl and alpha-trifluoromethyl substituted alpha-amino acids (114 references).

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Synthetic strategies to alpha-trifluoromethyl and alpha-difluoromethyl substituted alpha-amino acids. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Chemical Society reviews

VOLUME: 37

Page Numbers: 1727-39

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ISSN: 0306-0012

DAY: 26

MONTH: 06

YEAR: 2008

Synthetic strategies to alpha-trifluoromethyl and alpha-difluoromethyl substituted alpha-amino acids. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Synthetic strategies to alpha-trifluoromethyl and alpha-difluoromethyl substituted alpha-amino acids.

AFFILIATION: Department of Organic Chemistry, FU Berlin, Takustrasse 3, D-14195, Berlin, Germany. koksch@chemie.fu-berlin.de.

Country: England

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MEDLINETA: Chem Soc Rev

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