Synthetic nanostructures inducing differentiation of human mesenchymal stem cells into neuronal lineage.

Synthetic nanostructures inducing differentiation of human mesenchymal stem cells into neuronal lineage. Research Abstract Details 

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Synthetic nanostructures inducing differentiation of human mesenchymal stem cells into neuronal lineage. Abstract Text:

Evelyn K F Yim,Stella W Pang,Kam W Leong,

Human mesenchymal stem cells (hMSCs) have been shown to trans-differentiate into neuronal-like cells by culture in neuronal induction media, although the mechanism is not well understood. Topography can also influence cellular responses including enhanced differentiation of progenitor cells. As extracellular matrix (ECM) in vivo comprises topography in the nanoscale, we hypothesize that nanotopography could influence stem cell differentiation into specific non-default pathways, such as transdifferentiation of hMSCs. Differentiation and proliferation of hMSCs were studied on nanogratings of 350 nm width. Cytoskeleton and nuclei of hMSCs were aligned and elongated along the nanogratings. Gene profiling and immunostaining showed significant up-regulation of neuronal markers such as microtubule-associated protein 2 (MAP2) compared to unpatterned and micropatterned controls. The combination of nanotopography and biochemical cues such as retinoic acid further enhanced the up-regulation of neuronal marker expressions, but nanotopography showed a stronger effect compared to retinoic acid alone on unpatterned surface. This study demonstrated the significance of nanotopography in directing differentiation of adult stem cells.

Synthetic nanostructures inducing differentiation of human mesenchymal stem cells into neuronal lineage. Publishing Authors By Initials

EK Yim,SW Pang,KW Leong,

For similar organic chemicals: hydrocarbons: hydrocarbons, acyclic: alkenes: polyenes: carotenoids: retinoids: vitamin a: tretinoin research abstracts see: organic chemicals: hydrocarbons: hydrocarbons, acyclic: alkenes: polyenes: carotenoids: retinoids: vitamin a: tretinoin research

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Synthetic nanostructures inducing differentiation of human mesenchymal stem cells into neuronal lineage. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Experimental cell research

VOLUME: 313

Page Numbers: 1820-9

Journal Abbreviation:

ISSN: 0014-4827

DAY: 12

MONTH: 03

YEAR: 2007

Synthetic nanostructures inducing differentiation of human mesenchymal stem cells into neuronal lineage. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 373226

Synthetic nanostructures inducing differentiation of human mesenchymal stem cells into neuronal lineage. Keywords Mesh Terms:

KEYWORDS: Tretinoin

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Synthetic nanostructures inducing differentiation of human mesenchymal stem cells into neuronal lineage. Information

Substance Name: Tretinoin

Registry Number: 302-79-4

Grant and Affiliation Information for Synthetic nanostructures inducing differentiation of human mesenchymal stem cells into neuronal lineage.

AFFILIATION: Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.

Country: United States

AGENCY: United States NIBIB

GRANT: EB003447

ACRONYM: EB

MEDLINETA: Exp Cell Res

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