Synthetic cinnamylphenol derivatives as cancer chemopreventive agents.

Synthetic cinnamylphenol derivatives as cancer chemopreventive agents. Research Abstract Details 

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Synthetic cinnamylphenol derivatives as cancer chemopreventive agents. Abstract Text:

Chihiro Ito,Masataka Itoigawa,Tetsufumi Kanematsu,Yuuki Imamura,Harukuni Tokuda,Hoyoku Nishino,Hiroshi Furukawa,

Several substituted cinnamylphenol (1,3-diphenylpropene) derivatives were synthesized and tested for their inhibitory activities against in vitro Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. The prenylated cinnamylphenols were found to show remarkably potent activity. Furthermore, prenylated cinnamylphenols (19 and 25) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These results indicate that some prenylated cinnamylphenols might be valuable as potential cancer chemopreventive agents (anti-tumor promoters).

Synthetic cinnamylphenol derivatives as cancer chemopreventive agents. Publishing Authors By Initials

C Ito,M Itoigawa,T Kanematsu,Y Imamura,H Tokuda,H Nishino,H Furukawa,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Synthetic cinnamylphenol derivatives as cancer chemopreventive agents. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: European journal of medicinal chemistry

VOLUME: 42

Page Numbers: 902-9

Journal Abbreviation:

ISSN: 0223-5234

DAY: 13

MONTH: 01

YEAR: 2007

Synthetic cinnamylphenol derivatives as cancer chemopreventive agents. Information

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LANGUAGE: eng

NlmUniqueID: 420510

Synthetic cinnamylphenol derivatives as cancer chemopreventive agents. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Synthetic cinnamylphenol derivatives as cancer chemopreventive agents. Information

Substance Name: Phenols

Registry Number: 0

Grant and Affiliation Information for Synthetic cinnamylphenol derivatives as cancer chemopreventive agents.

AFFILIATION: Faculty of Pharmacy, Meijo University, Tempaku-ku, Nagoya 468-8503, Japan.

Country: France

AGENCY: United States NCI

GRANT: CA17625

ACRONYM: CA

MEDLINETA: Eur J Med Chem

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