Synthetic byproducts of tocopherol oxidation as inhibitors of platelet function.

Synthetic byproducts of tocopherol oxidation as inhibitors of platelet function. Research Abstract Details 

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Synthetic byproducts of tocopherol oxidation as inhibitors of platelet function. Abstract Text:

R Mower,M Steiner,

Vitamin E and its fully oxidized form tocopherol quinone are known inhibitors of platelet aggregation. Previous results from our laboratory have shown that the quinone was approximately equal in effectiveness to vitamin E. A recent report of a far greater inhibitory activity of the quinone produced by nitric acid oxidation of vitamin E prompted this investigation. Our studies show that the unusually high inhibition of platelet aggregation, release and cyclooxygenase activity associated with nitric acid oxidized vitamin E is due to byproducts of the oxidation process and not due to tocopherol quinone. Treatment of vitamin E acetate, a substance of mild effect on aggregation and arachidonate metabolism of platelets, with nitric acid did not produce tocopherol quinone but exerted as potent an inhibition as oxidized vitamin E. We conclude that nitric acid oxidation is unsuitable for preparation of tocopherol quinone unless the latter is carefully isolated. Oxidation with permanganate proved to be an alternate method without these difficulties.

Synthetic byproducts of tocopherol oxidation as inhibitors of platelet function. Publishing Authors By Initials

R Mower,M Steiner,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research

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Synthetic byproducts of tocopherol oxidation as inhibitors of platelet function. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Prostaglandins

VOLUME: 24

Page Numbers: 137-47

Journal Abbreviation: Prostaglandins

ISSN: 0090-6980

DAY: 19

MONTH: Aug

YEAR: 1982

Synthetic byproducts of tocopherol oxidation as inhibitors of platelet function. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 320271

Synthetic byproducts of tocopherol oxidation as inhibitors of platelet function. Keywords Mesh Terms:

KEYWORDS: alpha-Tocopherol

MESH TERMS: analogs & derivatives

Chemical & Substance for Abstract: Synthetic byproducts of tocopherol oxidation as inhibitors of platelet function. Information

Substance Name: tocopherol acetate

Registry Number: 7695-91-2

Grant and Affiliation Information for Synthetic byproducts of tocopherol oxidation as inhibitors of platelet function.

AFFILIATION:

Country: UNITED STATES

AGENCY: United States NHLBI

GRANT: HL 22951

ACRONYM: HL

MEDLINETA: Prostaglandins

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