Synthesis, photophysical properties and in vitro photodynamic activity of axially substituted subphthalocyanines.

Synthesis, photophysical properties and in vitro photodynamic activity of axially substituted subphthalocyanines. Research Abstract Details 

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Synthesis, photophysical properties and in vitro photodynamic activity of axially substituted subphthalocyanines. Abstract Text:

Hu Xu,Xiong-Jie Jiang,Elaine Y M Chan,Wing-Ping Fong,Dennis K P Ng,Hu Xu,Xiong-Jie Jiang,Elaine Y M Chan,Wing-Ping Fong,Dennis K P Ng,

A new series of subphthalocyanines substituted axially with an oligoethylene glycol chain [SPcB(OCH(2)CH(2))(n)OH, n = 3 () or 4 ()] or a p-phenoxy oligoethylene glycol methyl ether chain [SPcBOC(6)H(4)(OCH(2)CH(2))(n)OCH(3), n = 2 () or 3 ()] have been synthesised by substitution reactions of boron subphthalocyanine chloride SPcBCl () with the corresponding oligoethylene glycols, and characterised with various spectroscopic methods and elemental analysis. The molecular structure of one of these compounds (subphthalocyanine ) has also been determined. As revealed by absorption spectroscopy, these compounds are essentially non-aggregated in DMF. The low aggregation tendency of these compounds results in a strong fluorescence emission and high efficiency to generate singlet oxygen. All these subphthalocyanines, being formulated with Cremophor EL, function as efficient photosensitisers and exhibit a high photocytotoxicity against HepG2 human hepatocarcinoma and HT29 human colon adenocarcinoma cells. The phenoxy analogues and show a relatively high photostability and are particularly potent towards these cell lines, with IC(50) values down to 0.02 microM.

Synthesis, photophysical properties and in vitro photodynamic activity of axially substituted subphthalocyanines. Publishing Authors By Initials

H Xu,XJ Jiang,EY Chan,WP Fong,DK Ng,H Xu,XJ Jiang,EY Chan,WP Fong,DK Ng,

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Synthesis, photophysical properties and in vitro photodynamic activity of axially substituted subphthalocyanines. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Organic & biomolecular chemistry

VOLUME: 5

Page Numbers: 3987-92

Journal Abbreviation: Org. Biomol. Chem.

ISSN: 1477-0520

DAY: 30

MONTH: 10

YEAR: 2007

Synthesis, photophysical properties and in vitro photodynamic activity of axially substituted subphthalocyanines. Information

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LANGUAGE: eng

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AFFILIATION: Department of Chemistry and Centre of Novel Functional Molecules, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China. dkpn@cuhk.edu.hk.

Country: England

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MEDLINETA: Org Biomol Chem

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