Synthesis of the acutumine spirocycle via a radical-polar crossover reaction.

Synthesis of the acutumine spirocycle via a radical-polar crossover reaction. Research Abstract Details 

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Synthesis of the acutumine spirocycle via a radical-polar crossover reaction. Abstract Text:

Fang Li,Steven L Castle,

A new radical-polar crossover reaction was developed that consists of intramolecular conjugate addition of an aryl radical followed by enolate formation and hydroxylation. A C-C bond, a C-O bond, and two congested stereocenters are created in the process. The product is obtained as a single isomer. The method was used to synthesize the spirocyclic subunit of the alkaloid acutumine.

Synthesis of the acutumine spirocycle via a radical-polar crossover reaction. Publishing Authors By Initials

F Li,SL Castle,

For similar organic chemicals: hydrocarbons: hydrocarbons, acyclic: alkenes: vinyl compounds research abstracts see: organic chemicals: hydrocarbons: hydrocarbons, acyclic: alkenes: vinyl compounds research

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Synthesis of the acutumine spirocycle via a radical-polar crossover reaction. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Organic letters

VOLUME: 9

Page Numbers: 4033-6

Journal Abbreviation: Org. Lett.

ISSN: 1523-7060

DAY: 31

MONTH: 08

YEAR: 2007

Synthesis of the acutumine spirocycle via a radical-polar crossover reaction. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100890393

Synthesis of the acutumine spirocycle via a radical-polar crossover reaction. Keywords Mesh Terms:

KEYWORDS: Vinyl Compounds

MESH TERMS: chemistry

Chemical & Substance for Abstract: Synthesis of the acutumine spirocycle via a radical-polar crossover reaction. Information

Substance Name: acutumine

Registry Number: 0

Grant and Affiliation Information for Synthesis of the acutumine spirocycle via a radical-polar crossover reaction.

AFFILIATION: Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM70483

ACRONYM: GM

MEDLINETA: Org Lett

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