Synthesis of tertiary alpha-hydroxy acids by silylene transfer to alpha-keto esters.

Synthesis of tertiary alpha-hydroxy acids by silylene transfer to alpha-keto esters. Research Abstract Details 

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Synthesis of tertiary alpha-hydroxy acids by silylene transfer to alpha-keto esters. Abstract Text:

Brett E Howard,K A Woerpel,Brett E Howard,K A Woerpel,

Alpha-keto esters can be converted into alpha-hydroxy acids in a single flask involving metal-catalyzed silylene transfer, 6pi-electrocyclization, Ireland-Claisen rearrangement, and hydrolysis. This reaction sequence is stereoselective and tolerates alkyl- and aryl-substituted alpha-keto ester substrates as well as an alpha-imino ester.

Synthesis of tertiary alpha-hydroxy acids by silylene transfer to alpha-keto esters. Publishing Authors By Initials

BE Howard,KA Woerpel,BE Howard,KA Woerpel,

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Synthesis of tertiary alpha-hydroxy acids by silylene transfer to alpha-keto esters. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Organic letters

VOLUME: 9

Page Numbers: 4651-3

Journal Abbreviation: Org. Lett.

ISSN: 1523-7060

DAY: 2

MONTH: 10

YEAR: 2007

Synthesis of tertiary alpha-hydroxy acids by silylene transfer to alpha-keto esters. Information

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LANGUAGE: eng

NlmUniqueID: 100890393

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Grant and Affiliation Information for Synthesis of tertiary alpha-hydroxy acids by silylene transfer to alpha-keto esters.

AFFILIATION: Department of Chemistry, University of California, Irvine, California 92697-2025, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM-54909

ACRONYM: GM

MEDLINETA: Org Lett

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