Synthesis of RNA using 2'-O-DTM protection.

Synthesis of RNA using 2'-O-DTM protection. Research Abstract Details 

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Synthesis of RNA using 2'-O-DTM protection. Abstract Text:

Andrey Semenyuk,Andras ,Tommy Johansson,Camilla Estmer-Nilsson,Peter Blomgren,Mathias ,Leif A Kirsebom,Marek Kwiatkowski,

tert-Butyldithiomethyl (DTM), a novel hydroxyl protecting group, cleavable under reductive conditions, was developed and applied for the protection of 2'-OH during solid-phase RNA synthesis. This function is compatible with all standard protecting groups used in oligonucleotide synthesis, and allows for fast and high-yield synthesis of RNA. Oligonucleotides containing the 2'-O-DTM groups can be easily deprotected under the mildest possible aqueous and homogeneous conditions. The preserved 5'-O-DMTr function can be used for high-throughput cartridge RNA purification.

Synthesis of RNA using 2'-O-DTM protection. Publishing Authors By Initials

A Semenyuk,A ,T Johansson,C Estmer-Nilsson,P Blomgren,M ,LA Kirsebom,M Kwiatkowski,

For similar inorganic chemicals: sulfur compounds research abstracts see: inorganic chemicals: sulfur compounds research

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Synthesis of RNA using 2'-O-DTM protection. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of the American Chemical Society

VOLUME: 128

Page Numbers: 12356-7

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 27

MONTH: Sep

YEAR: 2006

Synthesis of RNA using 2'-O-DTM protection. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

Synthesis of RNA using 2'-O-DTM protection. Keywords Mesh Terms:

KEYWORDS: Sulfur Compounds

MESH TERMS: chemistry

Chemical & Substance for Abstract: Synthesis of RNA using 2'-O-DTM protection. Information

Substance Name: RNA

Registry Number: 63231-63-0

Grant and Affiliation Information for Synthesis of RNA using 2'-O-DTM protection.

AFFILIATION: Department of Genetics and Pathology, Uppsala University, Sweden.

Country: United States

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MEDLINETA: J Am Chem Soc

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