The synthesis of ring-contracted derivatives of erythromycin A via intramolecular transesterification under microwave irradiation of 8,9-anhydroerythromycin A 6,9-hemiketal and its derivatives is described. It was found that microwave irradiation could significantly improve the yields and shorten the reaction times under either solvent-containing (method A) or solvent-free (method B) conditions.
Synthesis of ring-contracted erythromycin A derivatives via microwave-assisted intramolecular transesterification. Publishing Authors By Initials
Synthesis of ring-contracted erythromycin A derivatives via microwave-assisted intramolecular transesterification. Journal Published:
PUBLICATION TYPE: Research Support, Non-U.S. Gov
Journal: Molecules (Basel, Switzerland)
VOLUME: 12
Page Numbers: 2123-9
Journal Abbreviation:
ISSN: 1420-3049
DAY: 30
MONTH: 08
YEAR: 2007
Synthesis of ring-contracted erythromycin A derivatives via microwave-assisted intramolecular transesterification. Information
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LANGUAGE: eng
NlmUniqueID: 100964009
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Grant and Affiliation Information for Synthesis of ring-contracted erythromycin A derivatives via microwave-assisted intramolecular transesterification.
AFFILIATION: School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China.
Country: Switzerland
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MEDLINETA: Molecules
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