Synthesis of peptide ribonucleic acid (PRNA)-DNA chimera and interaction with DNA and RNA.

Synthesis of peptide ribonucleic acid (PRNA)-DNA chimera and interaction with DNA and RNA. Research Abstract Details 

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Synthesis of peptide ribonucleic acid (PRNA)-DNA chimera and interaction with DNA and RNA. Abstract Text:

Takehiko Wada,Yoshiki Maeda,Nobuya Sawa,Hirofumi Sato,Hyongi Chon,Shigenori Kanaya,Yoshihisa Inoue,

Recently, we have demonstrated that effective control of the recognition behavior of peptide ribonucleic acid (PRNA) with complementary DNA is possible through the anti-to-synorientational change of pyrimidine nucleobase induced by borate ester formation. In this study, DNA-PRNA chimera was prepared by the solidphase synthesis. In the DNA-PRNA chimeras, both PRNA and DNA domains work as recognition sites for the complementary DNA/RNAs to form stable complex, while DNA-RNA hybrids formed in the DNA domains of DNA-PRNA chimera should be substrates to the hydrolysis by RNase H and PRNA moieties work as recognition control/switching devices and as inhibitor for the hydrolysis by exonucleases. Interaction of the DNA-PRNA chimera with DNA and RNA has been discussed.

Synthesis of peptide ribonucleic acid (PRNA)-DNA chimera and interaction with DNA and RNA. Publishing Authors By Initials

T Wada,Y Maeda,N Sawa,H Sato,H Chon,S Kanaya,Y Inoue,

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Synthesis of peptide ribonucleic acid (PRNA)-DNA chimera and interaction with DNA and RNA. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nucleic acids symposium series (2004)

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Page Numbers: 21-2

Journal Abbreviation: Nucleic Acids Symp Ser (Oxf)

ISSN: 1746-8272

DAY: 21

MONTH: 11

YEAR: 2007

Synthesis of peptide ribonucleic acid (PRNA)-DNA chimera and interaction with DNA and RNA. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Synthesis of peptide ribonucleic acid (PRNA)-DNA chimera and interaction with DNA and RNA.

AFFILIATION: Institute of Multidisciplinary Research for Advanced Materials,Tohoku University, 2-1-1, Katahira, Aobaku, Sendai 980-8577, Japan.

Country: England

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MEDLINETA: Nucleic Acids Symp Ser (Oxf)

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