Synthesis of neplanocin F analogues as potential antiviral agents.

Synthesis of neplanocin F analogues as potential antiviral agents. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Synthesis of neplanocin F analogues as potential antiviral agents. Abstract Text:

Hongwang Zhang,Raymond F Schinazi,Chung K Chu,

Neplanocin F is a natural carbocyclic nucleoside. Herein, we describe the synthesis and antiviral activity of (+/-)-5'-deoxy-neplanocin F analogues. The key intermediate 4, synthesized from the commercially available (+/-)-2-azabicyclo[2.2.1]-hept-5-en-3-one (ABH), was utilized to prepare the target nucleosides. Among the target compounds, 5'-deoxyneplanocin F adenine exhibited moderate anti-HIV activity in human lymphocytes without any marked cytotoxicity.

Synthesis of neplanocin F analogues as potential antiviral agents. Publishing Authors By Initials

H Zhang,RF Schinazi,CK Chu,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure research

PUBMED ID PMID:

MEDLINE DATE:

Synthesis of neplanocin F analogues as potential antiviral agents. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Bioorganic & medicinal chemistry

VOLUME: 14

Page Numbers: 8314-22

Journal Abbreviation: Bioorg. Med. Chem.

ISSN: 0968-0896

DAY: 25

MONTH: 09

YEAR: 2006

Synthesis of neplanocin F analogues as potential antiviral agents. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9413298

Synthesis of neplanocin F analogues as potential antiviral agents. Keywords Mesh Terms:

KEYWORDS: Molecular Structure

MESH TERMS: isolation & purification

Chemical & Substance for Abstract: Synthesis of neplanocin F analogues as potential antiviral agents. Information

Substance Name: neplanocin F

Registry Number: 72877-51-1

Grant and Affiliation Information for Synthesis of neplanocin F analogues as potential antiviral agents.

AFFILIATION: The University of Georgia College of Pharmacy, Athens, GA 30602, USA.

Country: England

AGENCY: United States NIAID

GRANT: AI-50409

ACRONYM: AI

MEDLINETA: Bioorg Med Chem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Synthesis of neplanocin F analogues as potential antiviral agents Related Publications

• A deficient TLR2 signaling promotes airway mucin production in Mycoplasma pneumoniae-infected allergic mice.
• An image-based approach to measure the ferric ion diffusion coefficient in fricke gel dosimetry.
• Assays for nonhomologous end joining in extracts.
• Backpropagation Neural Network for Motion Analysis on Blood-pool Gated Single Photon Emission Computed Tomography.
• Determination of reaction intermediate structures in heme proteins.
• Differential expression of MUC1, MUC2, and MUC5AC in carcinomas of various sites: an immunohistochemical study.
• EUS could detect ascites missed by CT scan.
• Effects of growth factors on cell migration and alkaline phosphatase release.
• Enantioselective synthesis and antiviral activity of purine and pyrimidine cyclopentenyl C-nucleosides.
• Familial resemblance of adiposity-related parameters: results from a health check-up population in Taiwan.
• Heterogeneous reactions of SO2 with HOCl and HOBr on ice surfaces.
• IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection.
• MUC1, MUC2 and MUC5AC expressions in cardiac myxoma.
• Measuring the folding transition time of single RNA molecules.
• Mutation accumulation in the intestine and colon of mice deficient in two intracellular glutathione peroxidases.
• PAMAM dendrimers and branched polyethyleneglycol (nanoparticles) prodrugs of (-)-beta-D-(2R, 4R)-dioxolane-thymine (DOT) and their anti-HIV activity.
• Scale-up development of high-performance polymer matrix for DNA sequencing analysis.
• Synthesis of neplanocin F analogues as potential antiviral agents.
• Water soluble complexes of chitosan-g-MPEG and hyaluronic acid.
• [Calpain I inhibition prevents pacing-induced structural remodeling for atrial fibrillation in canine]
• [Coronary artery atherosclerotic plaque and stent visualizations by optical coherence tomography]
• [Correlation between the serum levels of interleukin-2 and soluble interleukin-2 receptor and the response to immunosuppressive therapy in severe aplastic anemia patients]
• [Dynamic changes and significance of serum TNF-alpha, IL-8 levels in patients with acute respiratory distress syndrome after severe trauma]
• [Irinotecan plus cisplatin for the treatment of advanced non-small cell lung cancer]
• [Lead expelling effect of carboxymethyl chitosan calcium in lead poisoned mice]
• [Natural killer-like T-cell lymphoma/leukemia--a case report and literature review]
• [Phase I/II clinical trial of weekly administration of docetaxel plus cisplatin for advanced non-small cell lung cancer]
• [Polymorphism of HLA-DRB1 in Han population in Yunnan and comparison with 9 Han populations]
• [Risk factors for postoperative gastroparesis syndrome after pancreaticoduodenectomy with binary logistic regression.]
• [Visualization of intimal proliferation of drug-eluting stent and bare mental stent by use of optical coherence tomography]