Synthesis of N-Alkyl-octahydroisoquinolin-1-one-8-carboxamide Libraries Using a Tandem Diels-Alder/Acylation Sequence.

Synthesis of N-Alkyl-octahydroisoquinolin-1-one-8-carboxamide Libraries Using a Tandem Diels-Alder/Acylation Sequence. Research Abstract Details 

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Synthesis of N-Alkyl-octahydroisoquinolin-1-one-8-carboxamide Libraries Using a Tandem Diels-Alder/Acylation Sequence. Abstract Text:

Kevin J Frankowski,Erin E Hirt,Yibin Zeng,Ben Neuenswander,Drew Fowler,Frank Schoenen,Jeffrey ,Kevin J Frankowski,Erin E Hirt,Yibin Zeng,Ben Neuenswander,Drew Fowler,Frank Schoenen,Jeffrey ,

A synthetic sequence was developed in which a diene containing an attached secondary amine was reacted with maleic anhydride to afford the title structures in one step. The reaction involves a Diels-Alder reaction combined with a transacylation reaction of the imide group. A series of six scaffolds was constructed using this methodology. Each scaffold was subsequently reacted with 12 amines to afford a library containing 72 compounds.

Synthesis of N-Alkyl-octahydroisoquinolin-1-one-8-carboxamide Libraries Using a Tandem Diels-Alder/Acylation Sequence. Publishing Authors By Initials

KJ Frankowski,EE Hirt,Y Zeng,B Neuenswander,D Fowler,F Schoenen,J ,KJ Frankowski,EE Hirt,Y Zeng,B Neuenswander,D Fowler,F Schoenen,J ,

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Synthesis of N-Alkyl-octahydroisoquinolin-1-one-8-carboxamide Libraries Using a Tandem Diels-Alder/Acylation Sequence. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of combinatorial chemistry

VOLUME: 9

Page Numbers: 1188-92

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ISSN: 1520-4766

DAY: 27

MONTH: 09

YEAR: 2007

Synthesis of N-Alkyl-octahydroisoquinolin-1-one-8-carboxamide Libraries Using a Tandem Diels-Alder/Acylation Sequence. Information

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LANGUAGE: eng

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AFFILIATION: jaube@ku.edu.

Country: United States

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MEDLINETA: J Comb Chem

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