Synthesis of flavonoid analogues as scaffolds for natural product-based combinatorial libraries.

Synthesis of flavonoid analogues as scaffolds for natural product-based combinatorial libraries. Research Abstract Details 

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Synthesis of flavonoid analogues as scaffolds for natural product-based combinatorial libraries. Abstract Text:

Nianhuan Yao,Aiming Song,Xiaobing Wang,Seth Dixon,Kit S Lam,

The design and synthesis of flavonoid analogues as combinatorial scaffolds is reported. Using commercially available materials, we synthesized chalcones with fluoro and carboxy groups. Nitration of these compounds generated highly functionalized flavonoid scaffolds with an o-fluoronitrobenzene template. Subsequent cyclizations of these chalcones resulted in the formation of several flavone and flavonone scaffolds. One of the flavonones was chosen as the scaffold to synthesize flavonoid derivatives on the solid phase. A series of flavonoid derivatives were obtained in high yields, which demonstrates that these highly functionalized scaffolds can be used in the synthesis of natural product-based combinatorial libraries for drug discovery.

Synthesis of flavonoid analogues as scaffolds for natural product-based combinatorial libraries. Publishing Authors By Initials

N Yao,A Song,X Wang,S Dixon,KS Lam,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure research

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Synthesis of flavonoid analogues as scaffolds for natural product-based combinatorial libraries. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of combinatorial chemistry

VOLUME: 9

Page Numbers: 668-76

Journal Abbreviation:

ISSN: 1520-4766

DAY: 8

MONTH: 05

YEAR: 2007

Synthesis of flavonoid analogues as scaffolds for natural product-based combinatorial libraries. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100886263

Synthesis of flavonoid analogues as scaffolds for natural product-based combinatorial libraries. Keywords Mesh Terms:

KEYWORDS: Molecular Structure

MESH TERMS: chemistry

Chemical & Substance for Abstract: Synthesis of flavonoid analogues as scaffolds for natural product-based combinatorial libraries. Information

Substance Name: Flavonoids

Registry Number: 0

Grant and Affiliation Information for Synthesis of flavonoid analogues as scaffolds for natural product-based combinatorial libraries.

AFFILIATION: Division of Hematology & Oncology, Department of Internal Medicine, UC-Davis Medical Center, 4501 X Street, Sacramento, California 95817, USA.

Country: United States

AGENCY: United States NCI

GRANT: U19CA113298

ACRONYM: CA

MEDLINETA: J Comb Chem

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