Synthesis of aza-analogues of the glycosylated tyrosine portion of mannopeptimycin-E.

Synthesis of aza-analogues of the glycosylated tyrosine portion of mannopeptimycin-E. Research Abstract Details 

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Synthesis of aza-analogues of the glycosylated tyrosine portion of mannopeptimycin-E. Abstract Text:

Sanjeeva R Guppi,George A O'Doherty,

Two C4' amido disaccharide analogues of mannopeptimycin-E were synthesized via an iterative palladium glycosylation sequence. The stereoselective synthesis of the C4' acylated 1,4-alpha,alpha-manno,manno-amido disaccharide has been achieved in ten steps from a protected d-tyrosine. The path relies upon a regio- and diastereoselective palladium-catalyzed azide substitution reaction. The competence of the synthesis is demonstrated by the good overall yield (21%) from protected tyrosine.

Synthesis of aza-analogues of the glycosylated tyrosine portion of mannopeptimycin-E. Publishing Authors By Initials

SR Guppi,GA O'Doherty,

For similar amino acids, peptides, and proteins: amino acids: amino acids, cyclic: amino acids, aromatic: tyrosine research abstracts see: amino acids, peptides, and proteins: amino acids: amino acids, cyclic: amino acids, aromatic: tyrosine research

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Synthesis of aza-analogues of the glycosylated tyrosine portion of mannopeptimycin-E. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Journal of organic chemistry

VOLUME: 72

Page Numbers: 4966-9

Journal Abbreviation: J. Org. Chem.

ISSN: 0022-3263

DAY: 26

MONTH: 05

YEAR: 2007

Synthesis of aza-analogues of the glycosylated tyrosine portion of mannopeptimycin-E. Information

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LANGUAGE: eng

NlmUniqueID: 2985193

Synthesis of aza-analogues of the glycosylated tyrosine portion of mannopeptimycin-E. Keywords Mesh Terms:

KEYWORDS: Tyrosine

MESH TERMS: chemistry

Chemical & Substance for Abstract: Synthesis of aza-analogues of the glycosylated tyrosine portion of mannopeptimycin-E. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for Synthesis of aza-analogues of the glycosylated tyrosine portion of mannopeptimycin-E.

AFFILIATION: Department of Chemistry, West Virginia University, Morgantown, West Virginia 26506, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM63150

ACRONYM: GM

MEDLINETA: J Org Chem

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