Synthesis of 4,4-difluoroglycosides using ring-closing metathesis.

Synthesis of 4,4-difluoroglycosides using ring-closing metathesis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Synthesis of 4,4-difluoroglycosides using ring-closing metathesis. Abstract Text:

Christophe Audouard,John Fawcett,Gerry A Griffiths,Jonathan M Percy, Pintat,Clive A Smith,

4-Deoxy-4,4-difluoro-glycosides have been synthesised for the first time via a direct sequence involving ring-closing metathesis and indium-mediated difluoroallylation with 1-bromo-1,1-difluoropropene in water. Two protecting group strategies were explored, one to allow protection of the primary C-6 hydroxyl group throughout the sequence, while the second was intended to allow deprotection after RCM and before dihydroxylation. The benzyl ether could be used in the first role, and pivaloyl is effective in the second. Dihydroxylations were highly stereoselective and controlled by the orientation of the glycosidic C-O bond.

Synthesis of 4,4-difluoroglycosides using ring-closing metathesis. Publishing Authors By Initials

C Audouard,J Fawcett,GA Griffiths,JM Percy,S Pintat,CA Smith,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Synthesis of 4,4-difluoroglycosides using ring-closing metathesis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Organic & biomolecular chemistry

VOLUME: 2

Page Numbers: 528-41

Journal Abbreviation: Org. Biomol. Chem.

ISSN: 1477-0520

DAY: 28

MONTH: 01

YEAR: 2004

Synthesis of 4,4-difluoroglycosides using ring-closing metathesis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101154995

Synthesis of 4,4-difluoroglycosides using ring-closing metathesis. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Synthesis of 4,4-difluoroglycosides using ring-closing metathesis. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Synthesis of 4,4-difluoroglycosides using ring-closing metathesis.

AFFILIATION: Department of Chemistry, University of Leicester, University Road, Leicester, UK.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Org Biomol Chem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Synthesis of 4,4-difluoroglycosides using ring-closing metathesis Related Publications

• 10 do's and don'ts about tax homes.
• A gravitational lens.
• An animal evaluation of a paste of chitosan glutamate and hydroxyapatite as a synthetic bone graft material.
• An electrostrictive drive for fine pitch control in double-crystal monochromators.
• Animal model of human disease: inherited erythrocyte glutathione deficiency.
• Bacterial pathogens of the respiratory tract of the newborn infant.
• Brain uptake of nonsteroidal anti-inflammatory drugs: ibuprofen, flurbiprofen, and indomethacin.
• Calculating Society's Willingness to Pay for a QALY : Key Questions for Discussion.
• Characterizing the structures and folding of free proteins using 2-D gas-phase separations: observation of multiple unfolded conformers.
• Coccidioidomycosis.
• Demoralization, anhedonia and grief in patients with severe physical illness.
• Developmental outcomes after early or delayed insertion of tympanostomy tubes.
• Effects of hormone-induced superovulation on latent infectious bovine rhinotracheitis virus in cattle.
• Euphemistic codes and tell-tale hearts: humane assistance in end-of-life cases.
• Evaluation of beta-endorphin and naloxone on bovine uterine motility.
• Gastrointestinal disease in adolescents.
• Increased amyloid- levels in APPSWE transgenic mice treated chronically with a physiological high-fat high-cholesterol diet.
• Joys of teaching nursing.
• Occupational health in India.
• Odontoblast morphology and dental repair.
• Practical management of tuberculosis.
• Preventing and treating: Heart disease in women.
• Synthesis of 4,4-difluoroglycosides using ring-closing metathesis.
• The Herpesvirus capsid surface protein, VP26, and the majority of the tegument proteins are dispensable for capsid transport toward the nucleus.
• The effects of rhBMP-2 on human osteosarcoma cells and human gingival fibroblasts in vitro.
• The effects of xylazine hydrochloride on intrauterine pressure in the cow.
• The reliability of willingness to pay for changes in health status.
• The role of primary care in infertility management.
• What is happening in the real world in lipid therapy and is it appropriate? The need for a paradigm shift.
• X-ray Imaging and Microspectroscopy of Plants and Fungi.