Synthesis of (2S,4S)- and (2S,4R)-5-fluoroleucine and (2S,4S)-[5,5-2H2]-5-fluoroleucine.

Synthesis of (2S,4S)- and (2S,4R)-5-fluoroleucine and (2S,4S)-[5,5-2H2]-5-fluoroleucine. Research Abstract Details 

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Synthesis of (2S,4S)- and (2S,4R)-5-fluoroleucine and (2S,4S)-[5,5-2H2]-5-fluoroleucine. Abstract Text:

Jean-Damien Charrier,David S Hadfield,Peter B Hitchcock,Douglas W Young,

Syntheses of (2S,4S)- and (2S,4R)-5-fluoroleucine, and, and of (2S,4S)-[5,5-(2)H(2)]-5-fluoroleucine, have been completed. The methodology allows these compounds to be prepared in sufficient quantities for incorporation by solid-state protein synthesis into strategic sites in proteins for folding studies. X-ray structures of the epimers and have been obtained and show the presence of conformational isomerism. The torsion angles between the F-C bond and the main chain are compared with values found in a mutant of the protein ubiquitin in which (2S,4S)-5-fluoroleucine replaces leucine residues 50 and 67 in the native protein.

Synthesis of (2S,4S)- and (2S,4R)-5-fluoroleucine and (2S,4S)-[5,5-2H2]-5-fluoroleucine. Publishing Authors By Initials

JD Charrier,DS Hadfield,PB Hitchcock,DW Young,

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Synthesis of (2S,4S)- and (2S,4R)-5-fluoroleucine and (2S,4S)-[5,5-2H2]-5-fluoroleucine. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Organic & biomolecular chemistry

VOLUME: 2

Page Numbers: 474-82

Journal Abbreviation: Org. Biomol. Chem.

ISSN: 1477-0520

DAY: 28

MONTH: 01

YEAR: 2004

Synthesis of (2S,4S)- and (2S,4R)-5-fluoroleucine and (2S,4S)-[5,5-2H2]-5-fluoroleucine. Information

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LANGUAGE: eng

NlmUniqueID: 101154995

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AFFILIATION: Sussex Centre for Biomolecular Design and Drug Discovery, Department of Chemistry, University of Sussex, Falmer, Brighton, UK.

Country: England

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MEDLINETA: Org Biomol Chem

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