Synthesis of [18F]GBR13119, a presynaptic dopamine uptake antagonist.

Synthesis of [18F]GBR13119, a presynaptic dopamine uptake antagonist. Research Abstract Details 

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Synthesis of [18F]GBR13119, a presynaptic dopamine uptake antagonist. Abstract Text:

[18F]GBR13119 (1-[(4-[18F]fluorophenyl)-(phenyl)methoxy]ethyl-4-(3-phenylpropyl) piperazine) has been prepared in no carrier added form by a four-step synthesis from [18F]fluoride. Isolated yields are 7-10% (uncorrected) in a synthesis time of 120 min. The product is obtained in high specific activity (greater than 1000 Ci/mmol) and high radiochemical purity (greater than 99%) without chromatographic purification. Small amounts of chemical impurity, identified as the nitro-substituted analog by independent synthesis, can be removed by HPLC. [18F]GBR13119 is proposed as a new radiotracer for the presynaptic dopamine uptake system.

Synthesis of [18F]GBR13119, a presynaptic dopamine uptake antagonist. Publishing Authors By Initials

For similar heterocyclic compounds: heterocyclic compounds, 1-ring: piperazines research abstracts see: heterocyclic compounds: heterocyclic compounds, 1-ring: piperazines research

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Synthesis of [18F]GBR13119, a presynaptic dopamine uptake antagonist. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: International journal of radiation applications an

VOLUME: 39

Page Numbers: 279-82

Journal Abbreviation:

ISSN: 0883-2889

DAY: 26

MONTH: 02

YEAR: 1988

Synthesis of [18F]GBR13119, a presynaptic dopamine uptake antagonist. Information

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LANGUAGE: eng

NlmUniqueID: 8611097

Synthesis of [18F]GBR13119, a presynaptic dopamine uptake antagonist. Keywords Mesh Terms:

KEYWORDS: Piperazines

MESH TERMS: chemical synthesis

Chemical & Substance for Abstract: Synthesis of [18F]GBR13119, a presynaptic dopamine uptake antagonist. Information

Substance Name: GBR 13119

Registry Number: 76778-23-9

Grant and Affiliation Information for Synthesis of [18F]GBR13119, a presynaptic dopamine uptake antagonist.

AFFILIATION: Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109.

Country: UNITED STATES

AGENCY: United States NINDS

GRANT: 2-P01-NS15655

ACRONYM: NS

MEDLINETA: Int J Rad Appl Instrum [A]

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