Synthesis, Molecular Docking and PTP1B Inhibitory Activity of Functionalized 4,5-Dihydronaphthofurans and Dibenzofurans.

Synthesis, Molecular Docking and PTP1B Inhibitory Activity of Functionalized 4,5-Dihydronaphthofurans and Dibenzofurans. Research Abstract Details 

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Synthesis, Molecular Docking and PTP1B Inhibitory Activity of Functionalized 4,5-Dihydronaphthofurans and Dibenzofurans. Abstract Text:

Manish Dixit,Uzma Saeed,Amit Kumar,Mohammad Imran Siddiqi,Akhilesh K Tamrakar,Arvind K Srivastava,Atul Goel,

Protein tyrosine phosphatase 1B (PTP1B) is an enzyme that plays a critical role in down-regulating insulin signaling through dephosphorylation of the insulin receptor. Inhibitors of PTP1B showed increased insulin sensitivity and normalize plasma glucose level and thus are useful therapeutic agents for the treatment of diabetes. A series of functionalized 4,5-dihydronaphthofurans and dibenzofurans were synthesized, studied through molecular docking and evaluated for their PTP1B inhibitory activity.

Synthesis, Molecular Docking and PTP1B Inhibitory Activity of Functionalized 4,5-Dihydronaphthofurans and Dibenzofurans. Publishing Authors By Initials

M Dixit,U Saeed,A Kumar,MI Siddiqi,AK Tamrakar,AK Srivastava,A Goel,

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Synthesis, Molecular Docking and PTP1B Inhibitory Activity of Functionalized 4,5-Dihydronaphthofurans and Dibenzofurans. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Medicinal chemistry (Sh?ariqah, United Arab Emirat

VOLUME: 4

Page Numbers: 18-24

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ISSN: 1573-4064

DAY: 28

MONTH: Jan

YEAR: 2008

Synthesis, Molecular Docking and PTP1B Inhibitory Activity of Functionalized 4,5-Dihydronaphthofurans and Dibenzofurans. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Synthesis, Molecular Docking and PTP1B Inhibitory Activity of Functionalized 4,5-Dihydronaphthofurans and Dibenzofurans.

AFFILIATION: Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, India. agoel13@yahoo.com.

Country: Netherlands

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MEDLINETA: Med Chem

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