Synthesis, cytotoxicity, and hemolytic activity of 6'-O-substituted dioscin derivatives.

Synthesis, cytotoxicity, and hemolytic activity of 6'-O-substituted dioscin derivatives. Research Abstract Details 

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Synthesis, cytotoxicity, and hemolytic activity of 6'-O-substituted dioscin derivatives. Abstract Text:

Wei Li,Zaozao Qiu,Yibing Wang,Yichun Zhang,Ming Li,Jia Yu,Lihong Zhang,Ziyan Zhu,Biao Yu,Wei Li,Zaozao Qiu,Yibing Wang,Yichun Zhang,Ming Li,Jia Yu,Lihong Zhang,Ziyan Zhu,Biao Yu,

Dioscin derivatives (1-12) with a variety of substitutions at the 6'-OH of the chacotriosyl residue and the 3',6'-anhydrosaponin derivatives (26, 30, and 32) were synthesized. All these derivatives showed much lower cytotoxicity than that of the parent dioscin, while their hemolytic activities were partially retained depending on the various 6'-O-substitutions.

Synthesis, cytotoxicity, and hemolytic activity of 6'-O-substituted dioscin derivatives. Publishing Authors By Initials

W Li,Z Qiu,Y Wang,Y Zhang,M Li,J Yu,L Zhang,Z Zhu,B Yu,W Li,Z Qiu,Y Wang,Y Zhang,M Li,J Yu,L Zhang,Z Zhu,B Yu,

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Synthesis, cytotoxicity, and hemolytic activity of 6'-O-substituted dioscin derivatives. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Carbohydrate research

VOLUME: 342

Page Numbers: 2705-15

Journal Abbreviation: Carbohydr. Res.

ISSN: 0008-6215

DAY: 19

MONTH: 09

YEAR: 2007

Synthesis, cytotoxicity, and hemolytic activity of 6'-O-substituted dioscin derivatives. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Synthesis, cytotoxicity, and hemolytic activity of 6'-O-substituted dioscin derivatives.

AFFILIATION: State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.

Country: Netherlands

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MEDLINETA: Carbohydr Res

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