Synthesis, characterization and biodistribution studies of a neutral-lipophilic Tc-99m N3S2 chelate.

Synthesis, characterization and biodistribution studies of a neutral-lipophilic Tc-99m N3S2 chelate. Research Abstract Details 

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Synthesis, characterization and biodistribution studies of a neutral-lipophilic Tc-99m N3S2 chelate. Abstract Text:

P R Singh,M Corlija,D E Troutner,A R Ketring,W A Volkert,

Diaminedithiols (DADT) are known to form neutral-lipophilic complexes with 99mTc in aqueous solutions, where they are readily formed in high yields and demonstrate excellent stability. A new triaminedithiol (TADT) ligand was synthesized, characterized and shown to form a neutral-lipophilic 99mTc-chelate. The biodistribution of this 99mTc chelate in rats showed that its uptake in brain or heart following i.v. injection of the 99mTc chelate was low, but activity taken up was retained over a long period of time. The in vivo and in vitro properties of this chelate indicate the possibility that chemical modification of this TADT ligand may produce ligand systems that form 99mTc chelates with suitable diagnostic properties.

Synthesis, characterization and biodistribution studies of a neutral-lipophilic Tc-99m N3S2 chelate. Publishing Authors By Initials

PR Singh,M Corlija,DE Troutner,AR Ketring,WA Volkert,

For similar biochemical phenomena, metabolism, and nutrition: metabolism: pharmacokinetics: tissue distribution research abstracts see: biochemical phenomena, metabolism, and nutrition: metabolism: pharmacokinetics: tissue distribution research

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Synthesis, characterization and biodistribution studies of a neutral-lipophilic Tc-99m N3S2 chelate. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: International journal of radiation applications an

VOLUME: 19

Page Numbers: 791-5

Journal Abbreviation:

ISSN: 0883-2897

DAY: 21

MONTH: Oct

YEAR: 1992

Synthesis, characterization and biodistribution studies of a neutral-lipophilic Tc-99m N3S2 chelate. Information

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LANGUAGE: eng

NlmUniqueID: 8611098

Synthesis, characterization and biodistribution studies of a neutral-lipophilic Tc-99m N3S2 chelate. Keywords Mesh Terms:

KEYWORDS: Tissue Distribution

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: Synthesis, characterization and biodistribution studies of a neutral-lipophilic Tc-99m N3S2 chelate. Information

Substance Name: Technetium

Registry Number: 7440-26-8

Grant and Affiliation Information for Synthesis, characterization and biodistribution studies of a neutral-lipophilic Tc-99m N3S2 chelate.

AFFILIATION: Department of Radiology, Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65211.

Country: UNITED STATES

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MEDLINETA: Int J Rad Appl Instrum B

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