Synthesis and structure-activity relationships of spirohydantoin-derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1).

Synthesis and structure-activity relationships of spirohydantoin-derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Research Abstract Details 

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Synthesis and structure-activity relationships of spirohydantoin-derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Abstract Text:

Martin W Rowbottom,Troy D Vickers,Junko Tamiya,Mingzhu Zhang,Brian Dyck,Jonathan Grey,David Schwarz,Christopher E Heise,Michael Hedrick,Jenny Wen,Hui Tang,Hua Wang,Andrew Fisher,Anna Aparicio,John Saunders,Val S Goodfellow,

The design, synthesis, and SAR of a series of substituted spirohydantoins are described. Optimization of an in-house screening hit gave compounds that exhibited potent binding affinity and functional activity at MCH-R1.

Synthesis and structure-activity relationships of spirohydantoin-derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Publishing Authors By Initials

MW Rowbottom,TD Vickers,J Tamiya,M Zhang,B Dyck,J Grey,D Schwarz,CE Heise,M Hedrick,J Wen,H Tang,H Wang,A Fisher,A Aparicio,J Saunders,VS Goodfellow,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research

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MEDLINE DATE:

Synthesis and structure-activity relationships of spirohydantoin-derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 2171-8

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 0960-894X

DAY: 4

MONTH: 02

YEAR: 2007

Synthesis and structure-activity relationships of spirohydantoin-derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9107377

Synthesis and structure-activity relationships of spirohydantoin-derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Keywords Mesh Terms:

KEYWORDS: Structure-Activity Relationship

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Synthesis and structure-activity relationships of spirohydantoin-derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Information

Substance Name: melanin-concentrating hormone receptor

Registry Number: 0

Grant and Affiliation Information for Synthesis and structure-activity relationships of spirohydantoin-derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1).

AFFILIATION: Department of Medicinal Chemistry, Neurocrine Biosciences Inc., 12790 El Camino Real, San Diego, CA 92130, USA. mrowbottom@neurocrine.com

Country: England

AGENCY: United States NIDDK

GRANT: 2R44 DK 059107-02

ACRONYM: DK

MEDLINETA: Bioorg Med Chem Lett

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