Synthesis and spectral properties of near-infrared aminophenyl-, hydroxyphenyl-, and phenyl-substituted heptamethine cyanines.

Synthesis and spectral properties of near-infrared aminophenyl-, hydroxyphenyl-, and phenyl-substituted heptamethine cyanines. Research Abstract Details 

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Synthesis and spectral properties of near-infrared aminophenyl-, hydroxyphenyl-, and phenyl-substituted heptamethine cyanines. Abstract Text:

Hyeran Lee,J Christian Mason,Samuel Achilefu,Hyeran Lee,J Christian Mason,Samuel Achilefu,Hyeran Lee,J Christian Mason,Samuel Achilefu,

Diverse meso-aminophenyl-, hydroxyphenyl-, and phenyl-substituted heptamethine cyanine dyes were prepared by a modified Suzuki-Miyaura method in good yields. In addition, direct Suzuki coupling of Vilsmeier-Haack reagent extends the procedure to the synthesis of otherwise difficult cyanine dyes containing multiple heteroatoms in the indolium ring. The new compounds possess excellent spectral properties and can be used to label bioactive molecules and nanoparticles. The one-pot synthesis procedure eliminates the cumbersome steps of protecting/deprotecting amino or hydroxy groups.

Synthesis and spectral properties of near-infrared aminophenyl-, hydroxyphenyl-, and phenyl-substituted heptamethine cyanines. Publishing Authors By Initials

H Lee,JC Mason,S Achilefu,H Lee,JC Mason,S Achilefu,H Lee,JC Mason,S Achilefu,

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Synthesis and spectral properties of near-infrared aminophenyl-, hydroxyphenyl-, and phenyl-substituted heptamethine cyanines. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of organic chemistry

VOLUME: 73

Page Numbers: 723-5

Journal Abbreviation: J. Org. Chem.

ISSN: 0022-3263

DAY: 21

MONTH: 12

YEAR: 2007

Synthesis and spectral properties of near-infrared aminophenyl-, hydroxyphenyl-, and phenyl-substituted heptamethine cyanines. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Synthesis and spectral properties of near-infrared aminophenyl-, hydroxyphenyl-, and phenyl-substituted heptamethine cyanines.

AFFILIATION: Department of Radiology, Washington University, St. Louis, Missouri 63110 achilefus@mir.wustl.edu.

Country: United States

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MEDLINETA: J Org Chem

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