Synthesis and regulation of keratinocyte collagenase.

Synthesis and regulation of keratinocyte collagenase. Research Abstract Details 

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Synthesis and regulation of keratinocyte collagenase. Abstract Text:

We have recently demonstrated that human keratinocytes synthesize and secrete procollagenase and tissue inhibitor of metalloproteinases (TIMP) in culture. We have examined the response of keratinocyte collagenase production to the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), interleukin-1, extracellular matrix proteins and phagocytosis. Collagenase production in keratinocytes was markedly stimulated by TPA and paralleled the morphologic changes induced by the phorbol ester. Synthesis of collagenase increased six- to 34-fold with TPA, whereas the level of TIMP rose only three-fold. Interleukin-1 did not stimulate collagenase production by the keratinocytes, in contrast to its effect on cultured fibroblasts. When keratinocytes were plated on type I or type IV collagen, they synthesized increased amounts of collagenase compared with cells cultured on laminin or in the absence of matrix. TIMP synthesis was not increased by collagen. Finally, phagocytosis of latex beads did not augment collagenase production by the keratinocytes.

Synthesis and regulation of keratinocyte collagenase. Publishing Authors By Initials

For similar proteins: tissue inhibitor of metalloproteinases research abstracts see: proteins: tissue inhibitor of metalloproteinases research

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Synthesis and regulation of keratinocyte collagenase. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Matrix (Stuttgart, Germany). Supplement

VOLUME: 1

Page Numbers: 192-7

Journal Abbreviation:

ISSN: 0940-1199

DAY: 26

MONTH: 02

YEAR: 1992

Synthesis and regulation of keratinocyte collagenase. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9312140

Synthesis and regulation of keratinocyte collagenase. Keywords Mesh Terms:

KEYWORDS: Tissue Inhibitor of Metalloproteinases

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Synthesis and regulation of keratinocyte collagenase. Information

Substance Name: Collagenases

Registry Number: EC 3.4.24.-

Grant and Affiliation Information for Synthesis and regulation of keratinocyte collagenase.

AFFILIATION: Division of Dermatology, University of Utah, Salt Lake City.

Country: GERMANY

AGENCY: United States NIAMS

GRANT: AR36497

ACRONYM: AR

MEDLINETA: Matrix Suppl

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