Synthesis and mycobactericidal properties of metal complexes of isonicotinoyldithiocarbazic acid.

Synthesis and mycobactericidal properties of metal complexes of isonicotinoyldithiocarbazic acid. Research Abstract Details 

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Synthesis and mycobactericidal properties of metal complexes of isonicotinoyldithiocarbazic acid. Abstract Text:

S S Kanwar,K Lumba,S K Gupta,V M Katoch,P Singh,A K Mishra,S B Kalia,

An isonicotinoyldithiocarbazic acid (IN-DtczH) ligand, synthesized from isoniazid, was complexed with transition metals and evaluated for anti-mycobacterial activity as well as toxicity towards human-transformed rhabdomyosarcoma (RD) cells in vitro. Complexes with Ni, Co and Zn showed MIC of 2, 2 and 50 mug/ml against Mycobacterium tuberculosis H(37)Rv, and 10, 100 and 50 mug/ml against a multidrug-resistant strain of M. tuberculosis. They had little cytotoxic effect on the RD cells. In contrast, the Cu complex was highly cytotoxic with a low anti-mycobacterial activity.

Synthesis and mycobactericidal properties of metal complexes of isonicotinoyldithiocarbazic acid. Publishing Authors By Initials

SS Kanwar,K Lumba,SK Gupta,VM Katoch,P Singh,AK Mishra,SB Kalia,

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Synthesis and mycobactericidal properties of metal complexes of isonicotinoyldithiocarbazic acid. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biotechnology letters

VOLUME: 30

Page Numbers: 677-80

Journal Abbreviation: Biotechnol. Lett.

ISSN: 0141-5492

DAY: 17

MONTH: 11

YEAR: 2007

Synthesis and mycobactericidal properties of metal complexes of isonicotinoyldithiocarbazic acid. Information

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LANGUAGE: eng

NlmUniqueID: 8008051

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AFFILIATION: Department of Biotechnology, Himachal Pradesh University, Shimla, 171 005, India, kanwarss2000@yahoo.com.

Country: Netherlands

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MEDLINETA: Biotechnol Lett

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