Synthesis and matrix metalloproteinase (MMP)-12 inhibitory activity of ageladine A and its analogs.

Synthesis and matrix metalloproteinase (MMP)-12 inhibitory activity of ageladine A and its analogs. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Synthesis and matrix metalloproteinase (MMP)-12 inhibitory activity of ageladine A and its analogs. Abstract Text:

Naoki Ando,Shiro Terashima,

Ageladine A (1) and its analogs 2-10 were expeditiously synthesized by featuring the biosynthetic route proposed for 1 (for 1-10) and by employing 2-(N-t-butoxycarbonylamino)imidazol-4-carbaldehyde as the starting material (for 1-8). From MMP-12 inhibitory activity assay, it appeared evident that the two bromine atoms and the three NH groups (1-NH, 14-NH, and 15-NH2) were indispensable for 1 to exhibit excellent activity.

Synthesis and matrix metalloproteinase (MMP)-12 inhibitory activity of ageladine A and its analogs. Publishing Authors By Initials

N Ando,S Terashima,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research

PUBMED ID PMID:

MEDLINE DATE:

Synthesis and matrix metalloproteinase (MMP)-12 inhibitory activity of ageladine A and its analogs. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 4495-9

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 0960-894X

DAY: 6

MONTH: 06

YEAR: 2007

Synthesis and matrix metalloproteinase (MMP)-12 inhibitory activity of ageladine A and its analogs. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9107377

Synthesis and matrix metalloproteinase (MMP)-12 inhibitory activity of ageladine A and its analogs. Keywords Mesh Terms:

KEYWORDS: Structure-Activity Relationship

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Synthesis and matrix metalloproteinase (MMP)-12 inhibitory activity of ageladine A and its analogs. Information

Substance Name: Matrix Metalloproteinase 12

Registry Number: EC 3.4.24.65

Grant and Affiliation Information for Synthesis and matrix metalloproteinase (MMP)-12 inhibitory activity of ageladine A and its analogs.

AFFILIATION: Discovery Research Laboratories, Kyorin Pharmaceutical Co. Ltd, 2399-1, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. naoki.andou@mb.kyorin-pharm.co.jp

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Bioorg Med Chem Lett

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Synthesis and matrix metalloproteinase MMP-12 inhibitory activity of ageladine A and its analogs Related Publications

• Anterograde labeling of the corticospinal tract in jimpy mutant mice by Di I injection into the motor cortex.
• Conservative Decrease in Water Potential in Existing Leaves during New Leaf Expansion in Temperate and Tropical Evergreen Quercus Species.
• Distinct light responses of the adaxial and abaxial stomata in intact leaves of Helianthus annuus L.
• Expression of zebrafish ROR alpha gene in cerebellar-like structures.
• Further studies on the anerobic glycolysis of Yoshida sarcoma, and on effect of nitrogen mustard and p-chlor-mercuri-benzoate [Japanese text.]
• Ghrelin differentially modulates glucose-induced insulin secretion according to feeding status in sheep.
• Hepatic fibrosis and Fasciola hepatica infection in cattle.
• Leaf angle in Chenopodium album is determined by two processes: induction and cessation of petiole curvature.
• Non-photochemical loss in PSII in high- and low-light-grown leaves of Vicia faba quantified by several fluorescence parameters including L(NP), F0/F'm, a novel parameter.
• Permeabilities of composite membranes containing phospholipids.
• Relationships Between Quantum Yield for CO2 Assimilation, Activity of Key Enzymes and CO2 Leakiness in Amaranthus cruentus, a C4 Dicot, Grown in High or Low Light.
• Synthesis and matrix metalloproteinase (MMP)-12 inhibitory activity of ageladine A and its analogs.
• The pathways responsible for the characteristic head posture produced by lesions of the interstitial nucleus of Cajal in the cat.
• The role of electron transport in determining the temperature dependence of the photosynthetic rate in spinach leaves grown at contrasting temperatures.
• Three independent genetic profiles based on mucin expression in early differentiated-type gastric cancers--a new concept of genetic carcinogenesis of early differentiated-type adenocarcinomas.
• Vagal afferent C fibers projecting to the lateral descending trigeminal complex of crotaline snakes.
• [FROUNT, a regulator of monocytes/macrophage chemotaxis]
• [Genetic polymorphisms related to fluoropyrimidine sensitivity and toxicity.]
• [Results of pulmonary resection for metastatic lung tumors]
• [Staff education about patient's privacy]
• [Surgical therapy of HCG-producing mediastinal tumor accompanied with intrapulmonary metastasis]
• [Training of nurse administrators at our hospital: humane growth through various learning experiences]
• [Two cases of resection of small intestine with metastatic lesion of bronchogenic carcinoma after pulmonary resection]