A series of 4-aminoquinoline derivatives were synthesized by the reaction of 4-chloro-7-substituted-quinolines with the corresponding mono/dialkyl amines. The structures of the synthesized compounds were confirmed by NMR and FAB-MS spectral and elemental analyses. Subsequently, the compounds were examined for their cytotoxic effects on two different human breast tumor cell lines: MCF7 and MDA-MB468. Although all compounds examined were quite effective on both cell lines, the compound N'-(7-chloro-quinolin-4-yl)-N,N-dimethyl-ethane-1,2-diamine emerged as the most active compound of the series. It was particularly potent against MDA-MB 468 cells when compared to chloroquine and amodiaquine. The compound butyl-(7-fluoro-quinolin-4-yl)-amine showed more potent effects on MCF-7 cells when compared to chloroquine. Therefore, 4-aminoquinoline can serve as the prototype molecule for further development of a new class of anticancer agents.
Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives. Publishing Authors By Initials
Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives. Information
Number of References:
LANGUAGE: eng
NlmUniqueID: 8213295
Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives. Keywords Mesh Terms:
KEYWORDS:
MESH TERMS:
Chemical & Substance for Abstract: Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives. Information
Substance Name:
Registry Number:
Grant and Affiliation Information for Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives.
AFFILIATION: Tumour Biology Group, Northeastern Ontario Regional Cancer Program at the Sudbury Regional Hospital, 41 Ramsey Lake Road, Sudbury, Ontario P3E 5J1, Canada.
Country: France
AGENCY:
GRANT:
ACRONYM:
MEDLINETA: Biomed Pharmacother
REFSOURCE:
DATABASENAME:
ACCESSION NUMBER:
Number Hits: 0
Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives Related Publications
