Synthesis and Evaluation of Novel Biodegradable Hydrogels Based on Poly(ethylene glycol) and Sebacic Acid as Tissue Engineering Scaffolds.

Synthesis and Evaluation of Novel Biodegradable Hydrogels Based on Poly(ethylene glycol) and Sebacic Acid as Tissue Engineering Scaffolds. Research Abstract Details 

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Synthesis and Evaluation of Novel Biodegradable Hydrogels Based on Poly(ethylene glycol) and Sebacic Acid as Tissue Engineering Scaffolds. Abstract Text:

Jinku Kim,Kee-Won Lee,Theresa E Hefferan,Bradford L Currier,Michael J Yaszemski,Lichun Lu,Jinku Kim,Kee-Won Lee,Theresa E Hefferan,Bradford L Currier,Michael J Yaszemski,Lichun Lu,Jinku Kim,Kee-Won Lee,Theresa E Hefferan,Bradford L Currier,Michael J Yaszemski,Lichun Lu,Jinku Kim,Kee-Won Lee,Theresa E Hefferan,Bradford L Currier,Michael J Yaszemski,Lichun Lu,

Novel biodegradable poly(ethylene glycol) (PEG) based hydrogels, namely, PEG sebacate diacrylate (PEGSDA) were synthesized, and their properties were evaluated. Chemical structures of these polymers were confirmed by Fourier transform infrared and proton nuclear magnetic resonance ( (1)H NMR) spectroscopy. After photopolymerization, the dynamic shear modulus of the hydrogels was up to 0.2 MPa for 50% PEGSDA hydrogel, significantly higher than conventional hydrogels such as PEG diacrylate (PEGDA). The swelling ratios of these macromers were significantly lower than PEGDA. The in vitro degradation study demonstrated that these hydrogels were biodegradable with weight losses about 66% and 32% for 25% and 50% PEGSDA after 8 weeks of incubation in phosphate-buffered saline at 37 degrees C. In vitro biocompatibility was assessed using cultured rat bone marrow stromal cells (MSCs) in the presence of unreacted monomers or degradation products. Unlike conventional PEGDA hydrogels, PEGSDA hydrogel without RGD peptide modification induced MSC cell adhesion similar to tissue culture polystyrene. Finally, complex three-dimensional structures of PEGSDA hydrogels using solid free form technique were fabricated and their structure integrity was better maintained than PEGDA hydrogels. These hydrogels may find use as scaffolds for tissue engineering applications.

Synthesis and Evaluation of Novel Biodegradable Hydrogels Based on Poly(ethylene glycol) and Sebacic Acid as Tissue Engineering Scaffolds. Publishing Authors By Initials

J Kim,KW Lee,TE Hefferan,BL Currier,MJ Yaszemski,L Lu,J Kim,KW Lee,TE Hefferan,BL Currier,MJ Yaszemski,L Lu,J Kim,KW Lee,TE Hefferan,BL Currier,MJ Yaszemski,L Lu,J Kim,KW Lee,TE Hefferan,BL Currier,MJ Yaszemski,L Lu,

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Synthesis and Evaluation of Novel Biodegradable Hydrogels Based on Poly(ethylene glycol) and Sebacic Acid as Tissue Engineering Scaffolds. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biomacromolecules

VOLUME: 9

Page Numbers: 149-57

Journal Abbreviation: Biomacromolecules

ISSN: 1526-4602

DAY: 12

MONTH: 12

YEAR: 2007

Synthesis and Evaluation of Novel Biodegradable Hydrogels Based on Poly(ethylene glycol) and Sebacic Acid as Tissue Engineering Scaffolds. Information

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LANGUAGE: eng

NlmUniqueID: 100892849

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Grant and Affiliation Information for Synthesis and Evaluation of Novel Biodegradable Hydrogels Based on Poly(ethylene glycol) and Sebacic Acid as Tissue Engineering Scaffolds.

AFFILIATION: lu.lichun@mayo.edu.

Country: United States

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MEDLINETA: Biomacromolecules

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