Synthesis and characterization of silica-based hyper-crosslinked sulfonate-modified reversed stationary phases.

Synthesis and characterization of silica-based hyper-crosslinked sulfonate-modified reversed stationary phases. Research Abstract Details 

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Synthesis and characterization of silica-based hyper-crosslinked sulfonate-modified reversed stationary phases. Abstract Text:

Hao Luo,Lianjia Ma,Yu Zhang,Peter W Carr,Hao Luo,Lianjia Ma,Yu Zhang,Peter W Carr,

A novel type of silica-based sulfonate-modified reversed phase ((-)SO(3)-HC-C(8)) has been synthesized; it is based on a newly developed acid stable "hyper-crosslinked" C(8) derivatized reversed phase, denoted HC-C(8). The (-)SO(3)-HC-C(8) phases containing controlled amounts of sulfonyl groups were made by sulfonating the aromatic hyper-crosslinked network of the HC-C(8) phase at different temperatures. The (-)SO(3)-HC-C(8) phases are only slightly less hydrophobic than the parent HC-C(8) phase. The added sulfonyl groups provide a unique strong cation-exchange selectivity to the hydrophobic hyper-crosslinked substrate as indicated by the very large C coefficient as shown through Snyder's hydrophobic subtraction reversed-phase characterization method. This cation-exchange activity clearly distinguishes the sulfonated phase from all other reversed phases as confirmed by the very high values of Snyder's column comparison function F(s). In addition, as was found in previous studies of silica-based and zirconia-based reversed phases, a strong correlation between the cation-exchange interaction and hydrophobic interaction was observed for these sulfonated phases in studies of the retention of cationic solutes. The overall chromatographic selectivity of these (-)SO(3)-HC-C(8) phases is greatly enhanced by its high hydrophobicity through a "hydrophobically assisted" ion-exchange retention process.

Synthesis and characterization of silica-based hyper-crosslinked sulfonate-modified reversed stationary phases. Publishing Authors By Initials

H Luo,L Ma,Y Zhang,PW Carr,H Luo,L Ma,Y Zhang,PW Carr,

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Synthesis and characterization of silica-based hyper-crosslinked sulfonate-modified reversed stationary phases. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of chromatography. A

VOLUME: 1182

Page Numbers: 41-55

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ISSN: 0021-9673

DAY: 7

MONTH: 12

YEAR: 2007

Synthesis and characterization of silica-based hyper-crosslinked sulfonate-modified reversed stationary phases. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Synthesis and characterization of silica-based hyper-crosslinked sulfonate-modified reversed stationary phases.

AFFILIATION: Department of Chemistry, University of Minnesota, Smith and Kolthoff Hall, 207 Pleasant Street SE, Minneapolis, MN 55455, USA.

Country: Netherlands

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MEDLINETA: J Chromatogr A

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