Synthesis and characterization of a doxorubicin-Gd(III) contrast agent conjugate: a new approach toward prodrug-procontrast complexes.

Synthesis and characterization of a doxorubicin-Gd(III) contrast agent conjugate: a new approach toward prodrug-procontrast complexes. Research Abstract Details 

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Synthesis and characterization of a doxorubicin-Gd(III) contrast agent conjugate: a new approach toward prodrug-procontrast complexes. Abstract Text:

Luca Frullano,Baudilio Tejerina,Thomas J Meade,

We have prepared the first MRI prodrug-procontrast complex by conjugating doxorubicin to a Gd(III) chelate using an acid-labile linker. The relaxometric properties of the adduct and pH activation are reported.

Synthesis and characterization of a doxorubicin-Gd(III) contrast agent conjugate: a new approach toward prodrug-procontrast complexes. Publishing Authors By Initials

L Frullano,B Tejerina,TJ Meade,

For similar pharmaceutical preparations: prodrugs research abstracts see: pharmaceutical preparations: prodrugs research

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Synthesis and characterization of a doxorubicin-Gd(III) contrast agent conjugate: a new approach toward prodrug-procontrast complexes. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Inorganic chemistry

VOLUME: 45

Page Numbers: 8489-91

Journal Abbreviation:

ISSN: 0020-1669

DAY: 16

MONTH: Oct

YEAR: 2006

Synthesis and characterization of a doxorubicin-Gd(III) contrast agent conjugate: a new approach toward prodrug-procontrast complexes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 366543

Synthesis and characterization of a doxorubicin-Gd(III) contrast agent conjugate: a new approach toward prodrug-procontrast complexes. Keywords Mesh Terms:

KEYWORDS: Prodrugs

MESH TERMS: chemistry

Chemical & Substance for Abstract: Synthesis and characterization of a doxorubicin-Gd(III) contrast agent conjugate: a new approach toward prodrug-procontrast complexes. Information

Substance Name: Gadolinium DTPA

Registry Number: 80529-93-7

Grant and Affiliation Information for Synthesis and characterization of a doxorubicin-Gd(III) contrast agent conjugate: a new approach toward prodrug-procontrast complexes.

AFFILIATION: Department of Chemistry, Biochemistry and Molecular and Cell Biology, Neurobiology and Physiology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.

Country: United States

AGENCY: United States NCI

GRANT: U54CA119341

ACRONYM: CA

MEDLINETA: Inorg Chem

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