Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents.

Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents. Research Abstract Details 

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Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents. Abstract Text:

Chunhui Zhou,Jaeki Min,Zhigang Liu,Anne Young,Heather Deshazer,Tian Gao,Young-Tae Chang,Neville R Kallenbach,

Numerous studies have contributed to the development of natural and synthetic antimicrobial peptides as a prospective source of antibiotic agents. Based on the concept that cationic charge, bulk, and lipophilicity are major factors determining antibacterial activity in these peptides, we designed and screened several combinatorial libraries based on 1,3,5-triazine as a template. A set of compounds were identified to show potent antimicrobial activity together with low hemolytic activity.

Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents. Publishing Authors By Initials

C Zhou,J Min,Z Liu,A Young,H Deshazer,T Gao,YT Chang,NR Kallenbach,

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Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 18

Page Numbers: 1308-11

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 1464-3405

DAY: 11

MONTH: 01

YEAR: 2008

Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents. Information

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LANGUAGE: eng

NlmUniqueID: 9107377

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Grant and Affiliation Information for Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents.

AFFILIATION: Department of Chemistry, New York University, 100 Washington Square East, New York, NY 10003, USA.

Country: England

AGENCY: United States NCRR

GRANT: C06 RR-16572

ACRONYM: RR

MEDLINETA: Bioorg Med Chem Lett

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