Synthesis and biological evaluation of nitric oxide-releasing derivatives of oleanolic acid as inhibitors of HepG2 cell apoptosis.

Synthesis and biological evaluation of nitric oxide-releasing derivatives of oleanolic acid as inhibitors of HepG2 cell apoptosis. Research Abstract Details 

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Synthesis and biological evaluation of nitric oxide-releasing derivatives of oleanolic acid as inhibitors of HepG2 cell apoptosis. Abstract Text:

Li Chen,Yihua Zhang,Xiangwen Kong,Sixun Peng,Jide Tian,

A total of 106 nitric oxide-releasing derivatives of oleanolic acid were synthesized and their effects on the inhibition of anti-Fas-mediated HepG2 cell apoptosis were evaluated in vitro. Several compounds inhibited anti-Fas-mediated HepG2 cell apoptosis in a dose-dependent manner. Within this series of compounds, 8b is the most potent inhibitor. The development of new NO-releasing derivatives of oleanolic acid may aid in the design of NO-based medicines for the intervention of human liver inflammatory diseases.

Synthesis and biological evaluation of nitric oxide-releasing derivatives of oleanolic acid as inhibitors of HepG2 cell apoptosis. Publishing Authors By Initials

L Chen,Y Zhang,X Kong,S Peng,J Tian,

For similar polycyclic compounds research abstracts see: polycyclic compounds research

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Synthesis and biological evaluation of nitric oxide-releasing derivatives of oleanolic acid as inhibitors of HepG2 cell apoptosis. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 2979-82

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 0960-894X

DAY: 25

MONTH: 03

YEAR: 2007

Synthesis and biological evaluation of nitric oxide-releasing derivatives of oleanolic acid as inhibitors of HepG2 cell apoptosis. Information

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LANGUAGE: eng

NlmUniqueID: 9107377

Synthesis and biological evaluation of nitric oxide-releasing derivatives of oleanolic acid as inhibitors of HepG2 cell apoptosis. Keywords Mesh Terms:

KEYWORDS: Polycyclic Compounds

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Synthesis and biological evaluation of nitric oxide-releasing derivatives of oleanolic acid as inhibitors of HepG2 cell apoptosis. Information

Substance Name: Oleanolic Acid

Registry Number: 508-02-1

Grant and Affiliation Information for Synthesis and biological evaluation of nitric oxide-releasing derivatives of oleanolic acid as inhibitors of HepG2 cell apoptosis.

AFFILIATION: Center of Drug Discovery, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China.

Country: England

AGENCY: United States NCI

GRANT: CA116846

ACRONYM: CA

MEDLINETA: Bioorg Med Chem Lett

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