Synthesis and biological evaluation of cepharadiones A and B and related dioxoaporphines.

Synthesis and biological evaluation of cepharadiones A and B and related dioxoaporphines. Research Abstract Details 

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Synthesis and biological evaluation of cepharadiones A and B and related dioxoaporphines. Abstract Text:

Mark A Elban,Jean C Chapuis,Mei Li,Sidney M Hecht,

Described herein is the first total synthesis and structural confirmation of cepharadione A, a naturally occurring DNA damaging agent. Also reported is the synthesis of cepharadione B, a closely related natural product, as well as the biological evaluation of both natural products. Finally, the preparation and biological evaluation of novel dioxoaporphine analogues is described.

Synthesis and biological evaluation of cepharadiones A and B and related dioxoaporphines. Publishing Authors By Initials

MA Elban,JC Chapuis,M Li,SM Hecht,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research

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Synthesis and biological evaluation of cepharadiones A and B and related dioxoaporphines. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Bioorganic & medicinal chemistry

VOLUME: 15

Page Numbers: 6119-25

Journal Abbreviation: Bioorg. Med. Chem.

ISSN: 0968-0896

DAY: 20

MONTH: 06

YEAR: 2007

Synthesis and biological evaluation of cepharadiones A and B and related dioxoaporphines. Information

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LANGUAGE: eng

NlmUniqueID: 9413298

Synthesis and biological evaluation of cepharadiones A and B and related dioxoaporphines. Keywords Mesh Terms:

KEYWORDS: Structure-Activity Relationship

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Synthesis and biological evaluation of cepharadiones A and B and related dioxoaporphines. Information

Substance Name: cepharadione B

Registry Number: 55610-02-1

Grant and Affiliation Information for Synthesis and biological evaluation of cepharadiones A and B and related dioxoaporphines.

AFFILIATION: Departments of Chemistry and Biology, University of Virginia, Charlottesville, VA 22904, USA.

Country: England

AGENCY: United States NCI

GRANT: CA50771

ACRONYM: CA

MEDLINETA: Bioorg Med Chem

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