Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors.

Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors. Research Abstract Details 

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Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors. Abstract Text:

Jinho Lee,Hwangeun Choi,Kyoung-Hee Kim,Shinwu Jeong,Jong-Wook Park,Chul-Su Baek,Sei-Hee Lee,Jinho Lee,Hwangeun Choi,Kyoung-Hee Kim,Shinwu Jeong,Jong-Wook Park,Chul-Su Baek,Sei-Hee Lee,

A novel series of 3,5-diaminoindazoles were prepared and found to be CDK inhibitors. Potent inhibitors against CDK1 and CDK2 were obtained by introduction of 1lambda(6)-isothiazolidine-1,1-dioxide at 5-position of indazole. Anti-proliferative activities of compounds were evaluated using EJ, HCT116, SW620, and A549 cancer cell lines.

Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors. Publishing Authors By Initials

J Lee,H Choi,KH Kim,S Jeong,JW Park,CS Baek,SH Lee,J Lee,H Choi,KH Kim,S Jeong,JW Park,CS Baek,SH Lee,

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Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 18

Page Numbers: 2292-5

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ISSN: 1464-3405

DAY: 6

MONTH: 03

YEAR: 2008

Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors. Information

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LANGUAGE: eng

NlmUniqueID: 9107377

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Grant and Affiliation Information for Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors.

AFFILIATION: Department of Chemistry, Keimyung University, 1000 Sindang-Dong, Dalseo-Gu, Daegu 704-701, South Korea. jinho@kmu.ac.kr

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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