Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors.

Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors. Research Abstract Details 

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Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors. Abstract Text:

Kiev S Ly,Michael A Letavic,John M Keith,Jennifer M Miller,Emily M Stocking,Ann J Barbier,Pascal Bonaventure,Brian Lord,Xiaohui Jiang,Jamin D Boggs,Lisa Dvorak,Kirsten L Miller,Diane Nepomuceno,Sandy J Wilson,Nicholas I Carruthers,Kiev S Ly,Michael A Letavic,John M Keith,Jennifer M Miller,Emily M Stocking,Ann J Barbier,Pascal Bonaventure,Brian Lord,Xiaohui Jiang,Jamin D Boggs,Lisa Dvorak,Kirsten L Miller,Diane Nepomuceno,Sandy J Wilson,Nicholas I Carruthers,

The synthesis and biological activity of a new series of piperazine and diazepane amides is described. The new compounds are high affinity histamine H3 ligands and serotonin reuptake inhibitors.

Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors. Publishing Authors By Initials

KS Ly,MA Letavic,JM Keith,JM Miller,EM Stocking,AJ Barbier,P Bonaventure,B Lord,X Jiang,JD Boggs,L Dvorak,KL Miller,D Nepomuceno,SJ Wilson,NI Carruthers,KS Ly,MA Letavic,JM Keith,JM Miller,EM Stocking,AJ Barbier,P Bonaventure,B Lord,X Jiang,JD Boggs,L Dvorak,KL Miller,D Nepomuceno,SJ Wilson,NI Carruthers,

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Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 18

Page Numbers: 39-43

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 1464-3405

DAY: 13

MONTH: 11

YEAR: 2007

Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors. Information

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LANGUAGE: eng

NlmUniqueID: 9107377

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Grant and Affiliation Information for Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors.

AFFILIATION: Johnson & Johnson Pharmaceutical Research & Development L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA.

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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