Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents.

Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents. Research Abstract Details 

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Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents. Abstract Text:

Byoung-Kwon Chun,Peiyuan Wang,Abdalla Hassan,Jinfa Du,Phillip M Tharnish,Eisuke Murakami,Lieven Stuyver,Michael J Otto,Raymond F Schinazi,Kyoichi A Watanabe,

In order to study structure-activity relationships among the derivatives and congeners of 5',9-anhydro-3-(beta-D-ribofuranosyl)xanthine for anti-hepatitis C virus activity, a series of 5',9-anhydro-purine-isonucleosides with a substituent (s) at 6- or/and 8-position of the purine moiety were synthesized, and their anti-hepatitis C virus activity and cytotoxicity were evaluated and discussed.

Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents. Publishing Authors By Initials

BK Chun,P Wang,A Hassan,J Du,PM Tharnish,E Murakami,L Stuyver,MJ Otto,RF Schinazi,KA Watanabe,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus replication research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus replication research

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Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Nucleosides, nucleotides & nucleic acids

VOLUME: 26

Page Numbers: 83-97

Journal Abbreviation: Nucleosides Nucleotides Nuclei

ISSN: 1525-7770

DAY: 3

MONTH: 12

YEAR: 2007

Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100892832

Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents. Keywords Mesh Terms:

KEYWORDS: Virus Replication

MESH TERMS: drug effects

Chemical & Substance for Abstract: Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents. Information

Substance Name: RNA, Viral

Registry Number: 0

Grant and Affiliation Information for Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents.

AFFILIATION: Pharmasset, Inc., Princeton, New Jersey 08540, USA. kwon.chun@pharmasset.com

Country: United States

AGENCY: United States NIAID

GRANT: 1R43AI-056720

ACRONYM: AI

MEDLINETA: Nucleosides Nucleotides Nuclei

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