Synthesis and antimicrobial evaluation of new chalcones containing piperazine or 2,5-dichlorothiophene moiety.

Synthesis and antimicrobial evaluation of new chalcones containing piperazine or 2,5-dichlorothiophene moiety. Research Abstract Details 

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Synthesis and antimicrobial evaluation of new chalcones containing piperazine or 2,5-dichlorothiophene moiety. Abstract Text:

V Tomar,G Bhattacharjee, Kamaluddin,Ashok Kumar,

Two new series of chalcones have been synthesized by reacting 1-(4-piperazin-1-yl-phenyl)ethanone and 1-(2,5-dichloro-3-thienyl)-1-ethanone with different substituted benzaldehydes in turn by Claisen-Schmidt condensation. The compounds have been characterized by IR, (1)H NMR spectral and microanalysis data. All the synthesized compounds have been evaluated for antimicrobial activity. Some of these derivatives are potentially active against Gram-positive bacteria, Staphylococcus aureus and Escherichia coli while the most potent compound (1) in this study showed MIC(50) value of 2.22 microg/mL against Candida albicans.

Synthesis and antimicrobial evaluation of new chalcones containing piperazine or 2,5-dichlorothiophene moiety. Publishing Authors By Initials

V Tomar,G Bhattacharjee, Kamaluddin,A Kumar,

For similar thiophenes research abstracts see: thiophenes research

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Synthesis and antimicrobial evaluation of new chalcones containing piperazine or 2,5-dichlorothiophene moiety. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 5321-4

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 0960-894X

DAY: 15

MONTH: 08

YEAR: 2007

Synthesis and antimicrobial evaluation of new chalcones containing piperazine or 2,5-dichlorothiophene moiety. Information

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LANGUAGE: eng

NlmUniqueID: 9107377

Synthesis and antimicrobial evaluation of new chalcones containing piperazine or 2,5-dichlorothiophene moiety. Keywords Mesh Terms:

KEYWORDS: Thiophenes

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Synthesis and antimicrobial evaluation of new chalcones containing piperazine or 2,5-dichlorothiophene moiety. Information

Substance Name: Ciprofloxacin

Registry Number: 85721-33-1

Grant and Affiliation Information for Synthesis and antimicrobial evaluation of new chalcones containing piperazine or 2,5-dichlorothiophene moiety.

AFFILIATION: Department of Chemistry, Indian Institute of Technology Roorkee (IIT R), Roorkee 247667, UA, India.

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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