Syntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma.

Syntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma. Research Abstract Details 

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Syntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma. Abstract Text:

Karel Pomeisl,Ivan Votruba, ,Radek Pohl,Karel Pomeisl,Ivan Votruba, ,Radek Pohl,Karel Pomeisl,Ivan Votruba, ,Radek Pohl,

In the present study, we synthesized a series of pyrimidine acyclic nucleoside phosphonates bearing a number of substituents in C-5 position of uracil moiety and in the N-1-side chain. In addition, we have investigated in particular the novel syntheses of fluorinated derivatives substituted in the N-1-side chain and uracil C-5 position because fluorine-containing substituents are often powerful modifiers of chemical and biological properties. The obtained compounds exhibit a considerable inhibitory potency of thymidine phosphorylase from SD-lymphoma. In contrast, the synthesized phosphonates are not efficient inhibitors of E. coli and human thymidine phosphorylase.

Syntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma. Publishing Authors By Initials

K Pomeisl,I Votruba,A ,R Pohl,K Pomeisl,I Votruba,A ,R Pohl,K Pomeisl,I Votruba,A ,R Pohl,

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Syntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nucleosides, nucleotides & nucleic acids

VOLUME: 26

Page Numbers: 1025-8

Journal Abbreviation: Nucleosides Nucleotides Nuclei

ISSN: 1525-7770

DAY: 6

MONTH: 12

YEAR: 2007

Syntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma. Information

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LANGUAGE: eng

NlmUniqueID: 100892832

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AFFILIATION: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic. pomeisl@uochb.cas.cz

Country: United States

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MEDLINETA: Nucleosides Nucleotides Nuclei

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