Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer.

Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer. Abstract Text:

Zongxiang Zhou,Andrea Flesken-Nikitin,David C Corney,Wei Wang,David W Goodrich,Pradip Roy-Burman,Alexander Yu Nikitin,

Pathways mediated by p53 and Rb are frequently altered in aggressive human cancers, including prostate carcinoma. To test directly the roles of p53 and Rb in prostate carcinogenesis, we have conditionally inactivated these genes in the prostate epithelium of the mouse. Inactivation of either p53 or Rb leads to prostatic intraepithelial neoplasia developing from the luminal epithelium by 600 days of age. In contrast, inactivation of both genes results in rapidly developing (median survival, 226 days) carcinomas showing both luminal epithelial and neuroendocrine differentiation. The resulting neoplasms are highly metastatic, resistant to androgen depletion from the early stage of development, and marked with multiple gene expression signatures commonly found in human prostate carcinomas. Interestingly, gains at 4qC3 and 4qD2.2 and loss at 14qA2-qD2 have been consistently found by comparative genomic hybridization. These loci contain such human cancer-related genes as Nfib, L-myc, and Nkx3.1, respectively. Our studies show a critical role for p53 and Rb deficiency in prostate carcinogenesis and identify likely secondary genetic alterations. The new genetically defined model should be particularly valuable for providing new molecular insights into the pathogenesis of human prostate cancer.

Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer. Publishing Authors By Initials

Z Zhou,A Flesken-Nikitin,DC Corney,W Wang,DW Goodrich,P Roy-Burman,AY Nikitin,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Cancer research

VOLUME: 66

Page Numbers: 7889-98

Journal Abbreviation:

ISSN: 1538-7445

DAY: 15

MONTH: Aug

YEAR: 2006

Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2984705

Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer.

AFFILIATION: Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853-6401, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Cancer Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer Related Publications

• Core-shell silica nanoparticles as fluorescent labels for nanomedicine.
• MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth.
• Prostate cancer associated with p53 and Rb deficiency arises from the stem/progenitor cell-enriched proximal region of prostatic ducts.
• Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer.
• Toxicity and biomedical imaging of layered nanohybrids in the mouse.
• [100th graduation of veterinary physicians]
• [Achievements of science applied to production]
• [Assessment of the cost of breeding]
• [Comparative study of anti-rabies vaccines for bovine use]
• [Echinococcosis and coral-shaped stone in the kidney.]
• [Economic effectiveness of antiepizootic measures in Aujeszky's disease of swine]
• [Economic loss from tuberculosis in marals]
• [Economic training of veterinarians]
• [Effect of superficial impregnation of DDT in control of bed bugs.]
• [Effectiveness of a native virus vaccine against Marek's disease]
• [Functional transcranial dopplerography in an atherosclerotic lesion of the carotid arteries]
• [Helminth infectivity of cattle on irrigated pastures]
• [Helminthiases on specialized farms]
• [Infestation of aquatic invertebrates with duck helminth larvae]
• [Mastitis in sheep]
• [Mastitis in sheep]
• [Methods of substances and organelles introduction in living cell for cell engineering technologies]
• [Paramphistomiasis of cattle]
• [Prevention and treatment of mastitis in sheep]
• [Science--production]
• [Technic of modified function test for synthesis of hippuric acid.]
• [The cycle of development of Gastrothylax crumenifer and the prevention of gastrothylosis]
• [The economic effectiveness of anti-brucellosis measures]
• [The rational periods for insemination of cows]
• [Tuberculosis cutis.]